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Found 19 clinical trials
A Trial of Lopinavir/Ritonavir Dosed According to the Who Pediatric Weight Band Dosing Guidelines

The main purpose of this study is to measure the amount of lopinavir/ritonavir (two anti-HIV medications) in the blood. Results from this study will be compared to the levels of the drugs

kaletra
HIV Vaccine
ritonavir
lopinavir/ritonavir
lopinavir
  • 426 views
  • 08 Nov, 2020
  • 58 locations
IFN Beta-1b and Ribavirin for Covid-19

As of 1 July 2020, more than 10 million people been confirmed to have infected by SARS-CoV-2, resulting in more than 500,000 deaths. No specific antiviral treatment for the SARS-CoV-2 is currently available, but existing medication could be repurposed. The investigators therefore propose to conduct an open-label randomized controlled trial …

SARS
antiviral drugs
critical illness
interferon
  • 0 views
  • 24 Jan, 2021
  • 1 location
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia.

Colchicine acts upstream in the cytokines cascade by inhibiting the NLRP3 inflammasome while IL-6 receptor antagonists (tocilizumab) block the end result of the cytokines cascade. Hence, adding colchicine to tocilizumab with the aim of blocking the early and end products of the cytokines cascade, might reduce the risk of developing …

  • 0 views
  • 10 Dec, 2021
  • 1 location
Randomised Evaluation of COVID-19 Therapy (RECOVERY)

RECOVERY is a randomised trial investigating whether treatment with Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin, Colchicine, IV Immunoglobulin (children only

cough
pneumonia
hydroxychloroquine
shortness of breath
lopinavir
  • 0 views
  • 19 Apr, 2022
  • 6 locations
Trial of Treatments for COVID-19 in Hospitalized Adults (DisCoVeRy)

may become part of the SoC for comparison(s) with new experimental treatment(s). In previous versions of the DisCoVeRy protocol, remdesivir, lopinavir/ritonavir with or without interferon ß-1a

hydroxychloroquine
lopinavir/ritonavir
remdesivir
SARS
lopinavir
  • 405 views
  • 07 Apr, 2022
  • 41 locations
Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV) (PLATCOV)

The trial will develop and validate a platform for quantitative assessment of antiviral effects in low-risk patients with high viral burdens and uncomplicated COVID-19. In this randomised open label, controlled, group sequential adaptive platform trial, we will assess the performance of three distinct types of intervention relative to control (no …

  • 0 views
  • 21 Mar, 2022
  • 4 locations
Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission

The study will explore the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among HIV-infected infants.

HIV Vaccine
antiretroviral therapy
ritonavir
hiv dna
antiretroviral
  • 210 views
  • 10 Nov, 2021
  • 51 locations
Dihydroartemisinin-Piperaquine in the Context of Antiretroviral Therapy (DPART)

Open-label prospective intensive pharmacokinetic study of dihydroartemisinin-piperaquine (DP) in HIV-infected children on efavirenz (EFV)-, lopinavir/ritonavir (LPV/r)-, or dolutegravir (DTG

hiv test
lopinavir/ritonavir
efavirenz
lopinavir
antiretroviral therapy
  • 0 views
  • 13 Apr, 2022
  • 1 location
Masitinib in Patients With Symptomatic Mild to Moderate COVID-19

The objective of the study is to evaluate the anti-viral efficacy of 3 different dosages of masitinib in patients with symptomatic mild to moderate COVID-19.

  • 0 views
  • 08 Dec, 2021
  • 6 locations
HIV-1 Infected Patients Phase II Trial Dual Combination Doravirine/Raltegravir Open Label

The objective of antiretroviral therapy (ART) is the maintenance of HIV viral suppression, the optimal condition to prevent disease progression, to optimize immune restoration, to prevent the development of viral resistance and to reduce viral transmission. Antiretroviral therapy has to be maintained long life over decades in the absence of …

  • 1 views
  • 12 Feb, 2021
  • 1 location