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Found 10 clinical trials
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Patients with Heart Failure and currently on a loop diuretic

The purpose of this study is to evaluate the action of the study drug on your kidneys and your ability to eliminate salt and water alongside a diuretic (furosemide). The information gathered during this clinical trial may support further drug development, including larger trials in patients with heart failure.  The study …

fatigue
heart failure
furosemide
  • 88 views
  • 23 Nov, 2020
  • 1 location
The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress and carDiac remOdeling in Heart Failure

The aim of the study is to compare the effects of torasemide and furosemide on clinical and biochemical parameters of hemodynamic and neurohormonal compensation and myocardial remodeling in patients with chronic heart failure with indications for use of loop diuretics. The study protocol 100 patients with heart failure NYHA (New …

torsemide
diuretics
loop diuretic
chronic heart failure
medical therapy
  • 12 views
  • 08 Nov, 2020
  • 1 location
Effectiveness of a Diuretic Algorithm in Clinical Stability in Heart Failure Patients

One of the challenges in treating patients with heart failure (HF) is achieving clinical stability and reducing the hospital readmission rate. A diuretic dose adjustment algorithm developed in the United States (Diuretic Treatment Algorithm, DTA) and later validated for use in Brazil (as the Algoritmo de Ajuste de Diurtico, AAD) …

diuretics
furosemide
diuretic therapy
congestion
  • 8 views
  • 08 Nov, 2020
  • 1 location
Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients

The ReBIC-1 trial was designed to evaluate the potential clinical risks and benefits of withdrawing furosemide use in stable, apparently euvolemic, chronic HF outpatients in a multicentric double-blinded randomized clinical trial.

potassium
ejection fraction
heart disease
enzyme inhibitors
chronic heart failure
  • 12 views
  • 08 Nov, 2020
Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis

Individuals with kidney failure receiving maintenance hemodialysis (HD) have high mortality rates, driven largely by cardiovascular causes. Volume-related factors are critical, modifiable contributors to cardiovascular complications. Reversing volume overload has been shown to improve blood pressure and cardiac remodeling. Use of loop diuretics may represent a pragmatic, low-cost, and low-burden …

  • 0 views
  • 17 Nov, 2020
  • 5 locations
TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure

TRANSFORM-HF is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. Approximately 6,000 patients with heart failure will be enrolled. The primary objective of the TRANSFORM-HF study is to compare the treatment strategy of torsemide versus furosemide on clinical outcomes over 12 …

torsemide
ejection fraction
loop diuretic
b-type natriuretic peptide
heart failure
  • 306 views
  • 20 Dec, 2020
  • 58 locations
Weight-Based Torsemide Dosing in Subjects With Heart Failure

subjects randomized to standard of care therapy will be prescribed a daily fixed dose of a loop diuretic at hospital discharge and have a follow-up appointment within one week of discharge. All management

nesiritide
diuretics
torsemide
ejection fraction
natriuretic peptide
  • 18 views
  • 21 Sep, 2020
  • 1 location
Renal Stenting With Distal Atheroembolic Protection

Atherosclerotic renal artery stenosis (ARAS) is associated with progressive loss of renal function, refractory hypertension and flushing edema, responsible for mortality and morbidity, especially in the elderly. Current treatment includes restoration of the renal arterial lumen by endovascular stent placement and/or intensive medical therapy. There is no unanimous consent on …

atheroembolism
hypotensives
stent placement
glomerular filtration rate
chronic kidney disease
  • 8 views
  • 07 Nov, 2020
  • 1 location
Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study

A randomized controlled trial to test the potential safety and efficacy of LCSD in patients with heart failure due to non-ischemic and ischemic cardiomyopathy at the University of Cape Town. Left Cardiac Sympathetic Denervation (LCSD) is a surgical intervention that modulates the autonomic innervation of the cardiac system. This is …

ejection fraction
autonomic dysfunction
heart failure
ventricular tachycardia
non-ischaemic cardiomyopathy
  • 34 views
  • 08 Nov, 2020
  • 1 location
Efficacy and Safety of Dapagliflozin in Acute Heart Failure

This is a randomized trial of the addition of dapagliflozin to patients with diabetes hospitalized with acute decompensated heart failure (ADHF). Participants will be recruited following an initial standard evaluation in the ED and randomized within 24 hours of presentation for ADHF in a 1:1 fashion to protocolized diuretic therapy …

dyspnea
fluid overload
acute heart failure
loop diuretic
decompensated heart failure
  • 55 views
  • 27 May, 2020
  • 2 locations