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Found 14 clinical trials
9-ING-41 in Patients With Advanced Cancers

GSK-3 is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3 inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.

general anesthesia
doxorubicin
MRI
chemotherapy regimen
carboplatin
  • 542 views
  • 01 Aug, 2021
  • 16 locations
Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma

Glioblastoma multiforme (GBM) is the most common brain tumor in adults. The strikingly poor survival for patients with GBM (average survival 14-16 months following diagnosis) is due in part to limited early detection methods and an absence of effective therapeutic options. The study proposed would establish important evidence for the …

  • 0 views
  • 24 Feb, 2021
  • 1 location
Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma

Monocentric randomized phase I/II trial, including 24 patients diagnosed with relapsing glioblastoma (GBM) irrespective of MGMT and IDH gene status. Following diagnosis of relapsing glioblastoma by either brain CT scan or MRI, patients will be randomized in 2 arms: Arm 1: IMA950 mixed with Poly-ICLC administered subcutaneously Arm 2: Pembrolizumab …

measurable disease
poly iclc
dexamethasone
  • 46 views
  • 28 Jan, 2021
  • 1 location
Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRI

This research study aims to predict treatment response to anti-angiogenic therapy (Avastin) using advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) for Glioblastoma patients.

measurable disease
MRI
brain tumor
avastin
bevacizumab
  • 11 views
  • 26 Jan, 2021