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Found 13 clinical trials
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Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

It has been reported that radiation therapy followed by PCV chemotherapy (procarbazine, lomustine and vincristine) could improve progression-free survival (PFS) and overall survival (OS) in

temozolomide
lomustine
vincristine
  • 1 views
  • 24 Jan, 2021
  • 1 location
None
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of glioblastoma). Glioblastoma is one of the most malignant cancers. TTFields is a new treatment for brain cancer …

  • 0 views
  • 29 Sep, 2021
  • 1 location
None
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients

The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic

anaplastic astrocytoma
MRI
tumor progression
glioblastoma multiforme
astrocytoma, anaplastic
  • 0 views
  • 25 May, 2021
  • 120 locations
None
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

radiation from x-rays to kill cancer cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, vincristine sulfate, cyclophosphamide and lomustine, work in different ways to stop the growth of

MRI
platelet count
residual tumor
tumor cells
neutrophil count
  • 119 views
  • 03 Sep, 2021
  • 137 locations
None
A Phase II/III Study of High-dose Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme

In this study the investigators will evaluate the effect of high-dose, intermittent sunitinib versus treatment with lomustine in patients with recurrent glioblastoma multiforme. The

glioblastoma multiforme
measurable disease
platelet count
stereotactic radiosurgery
recurrent glioblastoma
  • 74 views
  • 01 May, 2021
  • 3 locations
None
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

) Arm C: evaluating the combination of selinexor with lomustine (or carmustine, if lomustine is not available) (S-L/C) in rGBM participants regardless of MGMT status Arm D: evaluating

MRI
platelet count
measurable disease
bevacizumab
temozolomide
  • 0 views
  • 03 Aug, 2021
  • 16 locations
None
A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer

The purpose of this study is to test the safety and tolerability of the research study drugs nivolumab, ipilimumab, lomustine, bevacizumab, and temozolomide when used following surgery and

  • 2 views
  • 26 Apr, 2021
  • 1 location
None
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

receive berubicin or lomustine for the evaluation of OS. Additional endpoints will include response and progression outcomes evaluated by a blinded central reviewer for each patient according to RANO

  • 0 views
  • 10 Oct, 2021
  • 35 locations
None
9-ING-41 in Patients With Advanced Cancers

GSK-3 is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3 inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.

gemcitabine
renal function
MRI
growth factor
solid tumor
  • 542 views
  • 01 Aug, 2021
  • 16 locations
None
Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma

This is a pilot neoadjuvant vaccine study in adults with WHO grade II glioma, for which surgical resection of the tumor is clinically indicated. Co-primary objectives are to determine: 1) the safety and feasibility of the neoadjuvant approach; and 2) whether the regimen increases the level of type-1 chemokine CXCL10 …

oligoastrocytoma
corticosteroids
poly iclc
poly-iclc
oligodendroglioma
  • 111 views
  • 12 Jun, 2021
  • 1 location