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Found 15 clinical trials
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A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur after Irradiation and Adjuvant Temozolomide Chemotherapy

The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma

  • 5 views
  • 11 Jun, 2020
  • 1 location
featured
OT-15-001 (STELLAR) A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After irradiation and Adjuvant Temozolomide Chemotherapy

People who were previously diagnosed with an anaplastic astrocytoma (WHO grade III astrocytoma) and now have evidence that their tumor has returned or has tarted to grow again without concern that it has progressed to a glioblastoma (WHO grade IV astrocytoma) may be eligible to participate.  This study is comparing …

brain tumor
astrocytoma
brain tumors
  • 10 views
  • 24 Jun, 2021
  • 1 location
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

It has been reported that radiation therapy followed by PCV chemotherapy (procarbazine, lomustine and vincristine) could improve progression-free survival (PFS) and overall survival (OS) in

temozolomide
vincristine
lomustine
  • 1 views
  • 24 Jan, 2021
  • 1 location
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of glioblastoma). Glioblastoma is one of the most malignant cancers. TTFields is a new treatment for brain cancer …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients

The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic

astrocytoma, anaplastic
tumor progression
glioblastoma multiforme
temozolomide
karnofsky performance status
  • 0 views
  • 25 May, 2021
  • 120 locations
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

radiation from x-rays to kill cancer cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, vincristine sulfate, cyclophosphamide and lomustine, work in different ways to stop the growth of

blood transfusion
residual tumor
mri of spine
x-rays
neutrophil count
  • 119 views
  • 31 Jul, 2021
  • 136 locations
A Phase II/III Study of High-dose Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme

In this study the investigators will evaluate the effect of high-dose, intermittent sunitinib versus treatment with lomustine in patients with recurrent glioblastoma multiforme. The

glioblastoma multiforme
neutrophil count
temozolomide
recurrent glioblastoma
EGFR
  • 74 views
  • 01 May, 2021
  • 3 locations
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

) Arm C: evaluating the combination of selinexor with lomustine (or carmustine, if lomustine is not available) (S-L/C) in rGBM participants regardless of MGMT status Arm D: evaluating

blood transfusion
neutrophil count
recurrent glioblastoma
MRI
cancer
  • 0 views
  • 01 Aug, 2021
  • 16 locations
A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer

The purpose of this study is to test the safety and tolerability of the research study drugs nivolumab, ipilimumab, lomustine, bevacizumab, and temozolomide when used following surgery and

  • 2 views
  • 26 Apr, 2021
  • 1 location
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

a 2:1 ratio to receive berubicin or lomustine for the evaluation of OS. Additional endpoints will include response and progression outcomes evaluated by a blinded central reviewer for each patient

  • 0 views
  • 21 Jul, 2021
  • 4 locations