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Found 44 clinical trials
PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer

This clinical study is aiming to determine the safest doses and schedule for the combination of two drugs named palbociclib and avelumab. The study will also be investigating how effective the combination is for a subgroup of breast cancer patients whose cancer expresses the androgen receptor (AR) but not the …

palbociclib
breast cancer
endocrine therapy
stage iv breast cancer
triple negative breast cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients

Young women with breast cancer have an increased breast tissue density and conventional imaging tests such as mammography and breast ultrasound are less sensitive and specific for detecting breast cancer than in older breast cancer patients. Breast MRI is an emerging tool that has been proven to improve the ability …

magnetic resonance imaging of breast
invasive breast cancer
hormone therapy
endocrine therapy
  • 4 views
  • 07 Nov, 2020
  • 2 locations
Study of Immunotherapy in Combination With Chemotherapy in HER2-negative Inflammatory Breast Cancer

This phase II multicentre randomized open-label study will assess the safety and efficacy of Pembrolizumab in combination with standard chemotherapy in inflammatory breast cancer. Pembrolizumab will be administered every 3 weeks during the neoadjuvant chemotherapy. Tissue and blood samples will be collected pre- and post-treatment for translational research.

erythema
cyclophosphamide
metastasis
neutrophil count
chromogenic in situ hybridization
  • 7 views
  • 25 Jan, 2021
  • 22 locations
Trastuzumab Optimization Trial in Breast Cancer

This is an open-label, randomised phase III, multicentre, Italian study designed to investigate the role of trastuzumab in patients with locally advanced and/or metastatic breast cancer over expressing HER2 who received a first line chemotherapy containing trastuzumab. The trial in divided in two studies: 1. The maintenance study will be …

  • 7 views
  • 07 Nov, 2020
  • 1 location
Pilot Investigation of Ultrasound Imaging and Spectroscopy and Ultrasound Imaging of Vascular Blood Flow as Early Indicators of Locally-Advanced Breast Cancer Response to Neoadjuvant Treatment

We have previously demonstrated that high-frequency ultrasound and spectroscopy, and recently conventional-frequency ultrasound and spectroscopy may be used to detect cell death in vitro, in situ and in vivo. The method can detect different forms of cell death and has been demonstrated to be sensitive to apoptotic, necrotic and mitotic …

  • 14 views
  • 25 Jan, 2021
  • 1 location
Follow-up in Early and Locally Advanced Breast Cancer Patients

A cross-sectional follow-up study of Early and Locally Advanced Breast Cancer patients after primary treatment.

advanced breast cancer
locally advanced breast cancer
endocrine therapy
hormone therapy
  • 0 views
  • 10 Apr, 2021
  • 12 locations
Use of Ultrasound Imaging and Spectroscopy as Early Indicators of Locally- Advanced Breast Cancer Response to Neoadjuvant Treatment

This work explores the possibility of using ultrasound imaging and spectroscopy as a way of monitoring cell death, hence, tumour response to treatment. The hypothesis here is that it can be used as a way of monitoring early response to cancer treatment and predicting which patients continue on in their …

measurable disease
advanced breast cancer
breast carcinoma
adjuvant therapy
carcinoma
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Pilot Study To Evaluate the Effectiveness of Pulsed Time-Domain Optical Spectroscopy for Monitoring the Responses in Neoadjuvant Treatments of Locally-Advanced Breast Cancer

complete response in women with locally advanced breast cancer receiving treatment with neoadjuvant treatments such as chemotherapy or neoadjuvant combined modality chemotherapy and radiotherapy.

adjuvant therapy
advanced breast cancer
breast cancer, treatment
locally advanced breast cancer
cancer treatment
  • 11 views
  • 23 Jan, 2021
  • 1 location
SENTINEL LYMPH NODE BIOPSY AFTER NEOADJUVANT CHEMOTHERAPY

study, the investigators evaluated factors affecting local recurrence and outcome in patients with locally advanced breast cancer (LABC), who underwent sentinel lymph node (SLN) with or without ALND

  • 0 views
  • 23 Jan, 2021
  • 1 location
Abemaciclib in Combination With Endocrine Therapy as First Line Therapy in Metastatic Breast Cancer Patients With Symp-tomatic Visceral Metastases or High Tumor Burden

Breast cancer is one of the most common cancers in women. 20-30 % of all breast cancer patients are faced with advanced disease, comprising both locally advanced breast cancer (LABC) and

  • 0 views
  • 31 Jan, 2021
  • 1 location