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Found 11 clinical trials
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Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC

This pilot trial studies how rigsertib sodium works in treating patients with Recessive Dystrophic Epidermolysis bullosa (RDEB) with locally advanced Squamous Cell Carcinoma (SCC). Rigosertib

  • 0 views
  • 08 Sep, 2021
  • 1 location
None
A Study of Debio 1143 (Xevinapant) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Suitable for Definitive Chemoradiotherapy

The primary objective of the study is to demonstrate superior efficacy of Debio 1143 vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and

  • 0 views
  • 29 Nov, 2021
  • 142 locations
None
A Study of Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Cancer of the Esophagus

squamous cell carcinoma (SCC) of the esophagus, with the aim to provide generalisable guidance for future clinical practice.

  • 0 views
  • 26 Jan, 2021
  • 2 locations
None
Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma

Cyclin D kinase 4 (CDK4) is a key regulator of the G1-S transition in the cell cycle. Alterations in CDK4-cyclin D-retinoblastoma (Rb) pathway may lead to carcinogenesis in many cancers. Several mechanisms have been described: (i) Amplification or overexpression of cyclin D1, (ii) Amplification of CDK4, (iii) Activating mutation of …

head and neck carcinoma
squamous cell carcinoma of head and neck
mouth cancer
squamous cell carcinoma
dental caries
  • 82 views
  • 25 Jan, 2021
  • 1 location
None
Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity

This is a randomized, open-label, prospective, pilot phase I/II study with focus on translational research and on the evaluation of the biological changes that are observed in sequential tumor tissue acquisition in patients with newly diagnosed advanced (stage IV) oral cavity SCC. Patients are treated with Durvalumab (arm A) or …

  • 0 views
  • 22 Jan, 2021
  • 1 location
None
Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)

Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. Theoretically, downstaging with neoadjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive thereby diminishing the chance for morbidity.

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
A Prospective Randomized Trial of Capecitabine Treatment in Patients With HNSCC

This prospective randomized controlled clinical Trial will be performed in patients with locally advanced squamous cell carcinoma of the head and neck. The objectives of the trial are to compare

head and neck carcinoma
squamous cell carcinoma of head and neck
immunomodulator
squamous cell carcinoma
adjuvant therapy
  • 4 views
  • 22 Jan, 2021
  • 1 location
None
A Reminder App to Reduce Radiation Dermatitis Rates in Patients With Head-and-Neck Cancer

locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). The primary endpoint is the rate of patients experiencing grade 2 radiation dermatitis at 60 Gy of radiotherapy. 80 patients are

  • 0 views
  • 26 Jan, 2021
  • 4 locations
None
MRI - Guided Adaptive RadioTHerapy for Reducing XerostomiA in Head and Neck Cancer (MARTHA-trial)

Radiotherapy is the main treatment for locally advanced squamous cell carcinoma of the head and neck (SCCHN). Many advances regarding tumor control and patient survival have been made over the

head and neck carcinoma
squamous cell carcinoma of head and neck
mouth cancer
squamous cell carcinoma
dental caries
  • 0 views
  • 08 May, 2021
  • 1 location
None
HFHS-1801-A Pilot Study of Immunotherapy as Consolidation Therapy for Patients With Recurrent Head and Neck Cancer

The study is a pilot study to explore the feasibility and efficacy of immunotherapy following salvage surgery for recurrent head and neck cancer.

head and neck carcinoma
squamous cell carcinoma of head and neck
salvage surgery
head and neck cancer
squamous cell carcinoma
  • 0 views
  • 23 Jan, 2021
  • 1 location