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Found 56 clinical trials
EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer (EXPERT)

This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I breast cancer of luminal A subtype defined using the Prosigna (PAM50) Assay.

  • 733 views
  • 04 May, 2022
  • 56 locations
Local Therapy for Oligorecurrent and Oligometastatic Esophageal Squamous Cell Carcinoma

The aim of the study is to determine if intervening with combined local therapy and chemotherapy prior to chemotherapy alone in patients with oligorecurrent and oligometastatic esophageal

  • 0 views
  • 09 Feb, 2022
  • 1 location
To Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of ABN401 in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer Harboring c-MET Dysregulation

This is a dose escalation, Phase 1-2 study of ABN401 in patients with advanced solid tumors, refractory metastatic disease, or refractory locally advanced disease not amenable to local therapy

  • 3 views
  • 16 May, 2022
  • 7 locations
Gemcitabine & Nab-Paclitaxel in Pancreatic Adenocarcinoma With Positive Peritoneal Cytology

frequency of cytologic conversion from positive to negative in such patients. The investigators also can begin to assess the value of maximum local therapy, including surgery, in patients who cytologically

pancreatic ductal adenocarcinoma
biliary stents
gemcitabine
pdac
measurable disease
  • 2 views
  • 15 Feb, 2022
  • 1 location
OMEGA, Local Ablative Therapy in Oligometastatic NSCLC (OMEGA)

Oligometastatic lung cancer (OM-NSCLC) seems to be associated with a better prognosis than usual Stage IV non-small cell lung cancer when radical local therapy of all metastatic sites is

carboplatin
ct scan
lung carcinoma
metastasis
brain metastases
  • 0 views
  • 24 Feb, 2022
  • 1 location
Prostate Cancer Subclinical Metastatic Ablative MR-guided Radiotherapy

In the clinical scenario of recurrent prostate cancer (PCa) post local therapy, current standard studies (bone scan and computed tomography) commonly fail to identify the recurrent disease

  • 5 views
  • 24 Mar, 2022
  • 1 location
High-Dose-Rate Brachytherapy

> This proposal is innovative in two fundamental ways: MRI-guidance, and specific tumor targeting for HDR brachytherapy. Successful completion of this study will further individualize local therapy

  • 9 views
  • 24 Jan, 2022
  • 1 location
SBRT in Early Breast Cancer in Elderly Women

Surgical treatment represents the standard of local therapy in patients with early breast cancer, however in women over75, the comorbidities related to aging reduce the possibility of candidates

  • 0 views
  • 16 Oct, 2021
  • 1 location
Microwave Ablation With MRI-Guided SBRT Boost in Renal Cell Carcinoma

The specific aims of this study are: To determine the safety and feasibility of treating patients with a combination of MRI guided stereotactic body radiation therapy and microwave ablation. To assess short and long-term toxicity rates of patients treated with a combined modality approach. To assess local control, survival, and …

metastasis
primary tumor
carcinoma
  • 6 views
  • 27 Jan, 2022
  • 1 location
Chemotherapy Followed by Irreversible Electroporation in Patients With Unresectable Locally Advanced Pancreatic Cancer (CHEMOFIRE-2)

This study is a single-arm clinical trial of irreversible electroporation (IRE) for the treatment of unresectable locally advanced pancreatic cancer (LAPC). The aim of the study is to evaluate the efficacy of IRE in this patient group. A statistical analysis of patient survival will be performed, comparing study participants to …

solid tumors
adenocarcinoma
carcinoma
cancer
  • 4 views
  • 16 Feb, 2022
  • 1 location