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Found 52 clinical trials
EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer

This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I breast cancer of luminal A subtype defined using the Prosigna (PAM50) Assay.

  • 685 views
  • 14 Apr, 2021
  • 47 locations
Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more …

vinorelbine
conventional surgery
etoposide
ifosfamide
doxorubicin
  • 103 views
  • 07 Nov, 2020
  • 9 locations
Ifosfamide and Doxorubicin Radiation Therapy and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma

RATIONALE: Drugs used in chemotherapy, such as ifosfamide and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to …

conventional surgery
ifosfamide
doxorubicin
combination chemotherapy
kidney function tests
  • 93 views
  • 07 Nov, 2020
  • 11 locations
Local Therapy for Oligorecurrent and Oligometastatic Esophageal Squamous Cell Carcinoma

The aim of the study is to determine if intervening with combined local therapy and chemotherapy prior to chemotherapy alone in patients with oligorecurrent and oligometastatic esophageal

  • 0 views
  • 28 Jan, 2021
  • 1 location
To Evaluate the Safety Pharmacokinetics Pharmacodynamics and Antitumor Activity of ABN401 in Patients With Advanced Solid Tumors

This is a dose escalation, Phase 1-2 study of ABN401 in patients with advanced solid tumors, refractory metastatic disease, or refractory locally advanced disease not amenable to local therapy

  • 3 views
  • 24 Jan, 2021
  • 8 locations
Gemcitabine & Nab-Paclitaxel in Pancreatic Adenocarcinoma With Positive Peritoneal Cytology

frequency of cytologic conversion from positive to negative in such patients. The investigators also can begin to assess the value of maximum local therapy, including surgery, in patients who cytologically

pdac
gemcitabine
ductal adenocarcinoma
pancreatic ductal adenocarcinoma
platelet count
  • 2 views
  • 24 Jan, 2021
  • 1 location
OMEGA Local Ablative Therapy in Oligometastatic NSCLC

Oligometastatic lung cancer (OM-NSCLC) seems to be associated with a better prognosis than usual Stage IV non-small cell lung cancer when radical local therapy of all metastatic sites is

lung carcinoma
stage iv non-small cell lung cancer
ct scan
brain metastases
carboplatin
  • 0 views
  • 23 Jan, 2021
  • 1 location
High-Dose-Rate Brachytherapy

> This proposal is innovative in two fundamental ways: MRI-guidance, and specific tumor targeting for HDR brachytherapy. Successful completion of this study will further individualize local therapy

  • 9 views
  • 14 Apr, 2021
  • 1 location
Prostate Cancer Subclinical Metastatic Ablative MR-guided Radiotherapy

In the clinical scenario of recurrent prostate cancer (PCa) post local therapy, current standard studies (bone scan and computed tomography) commonly fail to identify the recurrent disease

  • 5 views
  • 14 Apr, 2021
  • 1 location
A Clinical Trial of Stereotactic Ablative Radiotherapy for Metastatic Lymphadenopathy

, there is lack of validated prognostic factors to identify the patients who might benefit most from ablative local therapy for metastatic lymph node(s). The mechanism of effect of SABR on the cancer

  • 6 views
  • 22 Jan, 2021
  • 1 location