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Found 8 clinical trials
Radiotherapy Versus Low-Dose Tamoxifen Following Breast Conserving Surgery for Low-Risk Breast Ductal Carcinoma in Situ

Although the results obtained from ECOG E5194 cohort 1 (criteria: mammographically detected low- or intermediate-grade DCIS, measuring less than 2.5 cm with margins 3 mm) and RTOG 9804 trial (the same enrolled clinicopathological features to cohort 1 of ECOG E5194 trial) demonstrated that the 7-year ipsilateral breast tumor recurrence (IBTR) …

radiotherapy to breast
cancer
breast tumor
estrogen receptor
carcinoma in situ
  • 9 views
  • 12 Aug, 2019
  • 1 location
Making Informed Choices on Incorporating Chemoprevention Into Care (MiCHOICE)

This trial studies the implementation of decision support tools integrated into the electronic health record and patient portal for patients with atypical hyperplasia or lobular carcinoma in

  • 0 views
  • 15 Jan, 2021
  • 13 locations
Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer

This trial will investigate a novel 3-fraction radiation regimen for participants undergoing breast-conserving therapy (BCT) for early breast cancer that will: 1) significantly reduce the duration of treatment and can be completed in one-week (5 working days) and 2) MRI-guided radiotherapy (MRIdian) would limit the volume of normal tissue radiated …

cancer
carcinoma
partial breast irradiation
ductal carcinoma in situ
carcinoma in situ
  • 1 views
  • 16 Jan, 2021
  • 1 location
Ruxolitinib for Premalignant Breast Disease

This study is evaluating how ruxolitinib affects premalignant breast cells. One half of the study participants will receive ruxolitinib for approximately 15 days, and the other half will receive a placebo (sugar pill) for approximately 15 days. Once study participants have completed their ruxolitinib or placebo, participants will undergo surgery …

neutrophil count
clarithromycin
carcinoma in situ
antifungals
lobular carcinoma
  • 16 views
  • 22 Jun, 2020
  • 6 locations
Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

This randomized phase III trial studies metformin hydrochloride to see how well it works compared to placebo in preventing breast cancer in patients with atypical hyperplasia or in situ breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of metformin hydrochloride may prevent …

cancer
neutrophil count
lobular hyperplasia
carcinoma in situ
mammogram
  • 247 views
  • 17 Jan, 2021
  • 16 locations
Abemaciclib in Treating Patients With Surgically Resectable Chemotherapy Resistant Triple Negative Breast Cancer

This phase II trial studies how well abemaciclib works in treating patients with triple negative breast cancer that can be removed by surgery (resectable) and does not respond to treatment with chemotherapy. Abemaciclib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

progesterone receptor
5-fluorouracil
abemaciclib
erbb2
estrogen receptor
  • 6 views
  • 05 Jan, 2021
  • 6 locations
Genetics of Women With Lobular Carcinoma in Situ of the Breast

RATIONALE: Gathering information about genetic changes in patients with lobular carcinoma in situ of the breast may help doctors learn more about the disease and find better methods of

carcinoma in situ
lobular carcinoma
carcinoma
  • 46 views
  • 07 Nov, 2020
  • 1 location
High-Risk Breast Duct Epithelium

/2 or other hereditary genes mutation carriers. Women with cytologic or histologic evidence of ductal hyperplasia, atypical ductal hyperplasia, or lobular carcinoma in situ. Women

BRCA1
carcinoma
BRCA1/2
ductal carcinoma in situ
carcinoma in situ
  • 8 views
  • 15 Dec, 2020
  • 1 location