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Found 188 clinical trials
Tocotrienol Against the Progression of End Stage Liver Disease

The purpose of this Phase 2 trial is to validate the outcome observed in a previous trial that oral Tocotrienol (TCT) attenuates the rise in MELD score over time in patients with end stage liver disease / cirrhosis. The study is double blind and participants will be randomized to take …

meld score
tocotrienol
liver disease
nash
cirrhosis
  • 232 views
  • 21 Mar, 2022
  • 1 location
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

To study the effects on endothelial condition and short-term outcome in different strategies of plasma transfusion during liver transplantation in patients with end-stage liver disease.

cirrhosis
Accepts healthy volunteers
liver disease
liver transplant
  • 2 views
  • 25 Feb, 2022
  • 1 location
Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF (HBV)

This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.

hepatitis
serum total bilirubin level
hepatic failure
tenofovir
hepatitis b surface antigen
  • 3 views
  • 03 Feb, 2022
  • 1 location
Investigational Microbiota Restoration Therapeutic for Hepatic Encephalopathy

Individuals with cirrhosis are likely to develop overt hepatic encephalopathy for which diagnostic modalities and treatment options are limited. The purpose of this study is to determine if individuals with cirrhosis who experience hepatic encephalopathy would benefit from investigational microbiota restoration therapy due to their inherent cognitive alterations. Analysis for …

cirrhosis
encephalopathy
  • 0 views
  • 07 Oct, 2021
  • 1 location
Feasibility of an App-based Nutrition & Exercise Program in Cirrhosis

The personalized nutrition and exercise app was designed for use by individuals living with chronic conditions. The pilot study examines the acceptance and use of the online, interactive program to support self-management in cirrhosis.

cirrhosis
varices
elastography
  • 0 views
  • 29 May, 2022
  • 1 location
VE303 for Treatment of Hepatic Encephalopathy (HE)

This research is studying the use of a new drug to learn about its safety and efficacy as a treatment for hepatic encephalopathy. Eligible participants will be enrolled and given oral antibiotics followed by 14 days of the study drug (placebo vs.VE303). There will be visits as well as other …

lactulose
encephalopathy
rifaximin
cirrhosis
biopsy of liver
  • 0 views
  • 29 Sep, 2021
  • 1 location
Role of Sarcopenia and Nutritional/Physical Therapy Intervention in Post-TIPS Hepatic Encephalopathy

The placement of TIPS (transjugular intrahepatic portosystemic shunt) is the most effective strategy to treat complications of portal hypertension. However, the threat of developing post-TIPS complications diminishes its use and applicability. Hepatic encephalopathy (HE) is the most feared and frequent post-TIPS complication, affecting between 25-54% of patients. Available treatments against …

portosystemic shunt
encephalopathy
resistance training
hypertension
  • 0 views
  • 12 May, 2022
  • 3 locations
Effect of Brief Dietary Intervention on Ammonia Levels

Study the impact of differing meal contents on venous ammonia levels over time in patients with cirrhosis. Patients will be given specific meals and venous ammonia analyzed over time after those meals. The subjects will also provide stool for microbiome and serum, urine and plasma for metabolomics during this one-time …

  • 0 views
  • 25 May, 2022
  • 1 location
Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment

This study aims to investigate the efficacy and safety of avatrombopag for treating thrombocytopenia in hepatitis b virus related acute-on-chronic liver failure patients receiving artificial

avatrombopag
  • 0 views
  • 06 Jun, 2022
  • 1 location
ARAPS Study on Accelerated Liver Regeneration

Liver resection is the golden standard in the treatment of hepatic malignancies. The size and function of the remnant liver is a major concern. If the future liver remnant (FLR) is below 30 % of the initial liver volume, the risk of post hepatectomy liver insufficiency rises. Several techniques have …

  • 0 views
  • 31 Jan, 2021
  • 1 location