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Found 187 clinical trials
Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment

The primary purpose of this study is to evaluate the effect of hepatic impairment on the systemic pharmacokinetics, safety, and tolerability of icenticaftor in participants with varying degrees of hepatic impairment.

Accepts healthy volunteers
liver disease
hepatic impairment
  • 2 views
  • 14 Jun, 2022
  • 1 location
Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

This is a prospective, multi-center, controlled, randomized, pivotal study to evaluate the safety and effectiveness of the VitaSmart Liver Machine Perfusion System by comparing clinical outcomes in patients undergoing liver transplantation with ex-vivo liver preservation using static cold storage (SCS) followed by hypothermic oxygenated machine perfusion (HOPE) versus SCS only.

carcinoma
  • 0 views
  • 22 Mar, 2022
  • 1 location
Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function

This multi-center, open-label, parallel-controlled, single-dose Phase 1 study is being conducted to directly characterize the pharmacokinetic (PK) profiles and safety of Jaktinib following administration of a single oral dose in subjects with varying degrees of hepatic impairment compared to healthy matched control subjects with normal hepatic function(matched by age, weight, …

Accepts healthy volunteers
hepatic impairment
body mass index
cirrhosis
liver disease
  • 0 views
  • 10 Dec, 2021
  • 1 location
Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia

End stage liver disease is prone to thrombocytopenia. This study is a multi-center, randomized, prospective, randomized controlled Phase IV Clinical trial to discuss the Efficacy and Safety of Avatrombopag in Patients with End-stage Liver Disease and Thrombocytopenia.

avatrombopag
cirrhosis
liver disease
platelet count
  • 0 views
  • 16 Jun, 2021
  • 1 location
Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy

Efficacy and Safety of Nitazoxanide in preventing recurrence of Hepatic Encephalopathy.

rifaximin 550 mg
encephalopathy
rifaximin
  • 4 views
  • 18 Feb, 2022
  • 1 location
Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy and occurs because of impaired hepatic ureagenesis and increased skeletal muscle proteolysis. We propose a randomized, 6-month nutritional intervention in cirrhotic patients who have had at least 1 admission for …

hyperammonemia
encephalopathy
ct scan
liver disease
cirrhosis
  • 38 views
  • 18 Feb, 2022
  • 1 location
Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy (EMMPOWER)

This is a global study to compare the effects of AXA1665, an orally active mixture of amino acids, compared to placebo, on cognitive and physical function, as well as the safety and tolerability of AXA1665.

cirrhosis
encephalopathy
screening procedures
  • 0 views
  • 23 Mar, 2022
  • 21 locations
Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF (BCAA-ACLF)

This study analyses the effect of intravenous branched chain amino acids (BCAA) on overt HE in patients with ACLF. The investigators plan to study the efficacy of combining intravenous BCAA with lactulose versus lactulose alone in the medical management of overt HE in patients with ACLF and its impact on …

lactulose
branched chain amino acids
encephalopathy
amino acids
  • 7 views
  • 24 Feb, 2022
  • 1 location
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH)

TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure. The study

mediators
encephalopathy
liver injury
corticosteroids
  • 0 views
  • 09 Jun, 2022
  • 8 locations
Pulmonary Rehabilitation in End-Stage Liver Disease

The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program

liver transplant
liver disease
  • 17 views
  • 26 Feb, 2022
  • 1 location