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Found 191 clinical trials
The Markers and Paracetamol Poisoning Study 2

Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission. Treatment is with the antidote acetylcysteine (NAC), which is effective but takes 21 hours to administer intravenously and frequently produces adverse reactions. Current tools that are …

  • 0 views
  • 10 Sep, 2021
  • 1 location
Bowel Cleansing With Renal Impairment (BC-RIMP)

Bowel preparation for colonoscopy requires the administration of large amounts of fluids that can cause fluid and electrolyte disturbances and volume overload, especially in patients with advanced renal failure. Polyethylene glycol-based regimens are considered safe, even in patients with advanced renal failure. However, the incidence of adverse effects (AEs) in …

  • 0 views
  • 15 May, 2022
  • 2 locations
sCD163 in PBC Patients - Assessment of Treatment Response

Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) is the first line treatment for patients with PBC. However, up to 40% of patients respond inadequate to this treatment. sCD163 is a macrophage activation marker shedded into …

biopsy of liver
liver disease
fibroscan
cirrhosis
cholangitis
  • 30 views
  • 24 Feb, 2022
  • 1 location
Hepatic Resection for Metastatic Pancreatic Cancer

The purpose of this study is to demonstrate the feasibility of an aggressive multimodal approach among patients with stage IV pancreatic cancer (PAC) with isolated, low-volume hepatic metastasis (LVHM). We will evaluate and describe the surgical and overall outcomes of an initial cohort of subjects who undergo pancreatectomy and hepatic …

pancreatectomy
metastatic pancreatic cancer
metastasis
hepatectomy
liver metastasis
  • 34 views
  • 23 Mar, 2022
  • 1 location
Bezafibrate in Patients With Primary Biliary Cholangitis (PBC)

Up to 40% of patients with PBC have an inadequate response to standard treatment with UDCA, hence bezafibrate, a PPAR-agonist is being introduced as add-on therapy in these patients. sCD163, fibrosis markers and bile acid composition are of special interest in PBC. In this study, the investigators will investigate how …

  • 0 views
  • 26 Jan, 2021
  • 2 locations
Quantifying Body Composition and Liver Disease in Children Using Free-Breathing MRI and MRE

Magnetic resonance imaging (MRI) is used to measure liver fat content and fatty tissues in the body, and magnetic resonance elastography (MRE) is used to measure liver stiffness. The information from MRI and MRE are used to understand risk factors and diagnose liver diseases, such as fatty liver disease and …

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Impact of Hear Failure on Lungs in Patients With Heart Failure

Heart failure (HF) is a common disease, which impacts on other organs. Despite an ongoing progress in knowledge about HF, there are still some uncharted aspects of impact of HF on respiratory system. The aim of the study is to determine whether there are any differences in pulmonary changes assessed …

troponin
n-terminal pro-bnp
heart failure
chronic heart failure
  • 0 views
  • 05 Jun, 2022
  • 1 location
Derivation of New Human Embryonic Stem Cell Lines Lines for Clinical Use

Human embryonic stem cells (hESCs) are isolated from the early human embryo and have the capability to proliferate indefinitely in culture and to develop into nearly every cell of the human body. Therefore, hESCs may serve as a renewable unlimited source of cells for transplantation therapy. Because of the use …

blood test
Accepts healthy volunteers
  • 129 views
  • 24 Mar, 2022
  • 1 location
LiverMultiScan Analysis of MRI Scans in HCC

This project is a pilot study to interrogate the potential of LMS as a predictive tool for the selection of therapy for HCC patients. The reliability of LMS to predict patients' response following HCC therapy will leverage on an algorithm that is built from the pool of MRI scans from …

liver cancer
renal function
alpha fetoprotein
metastasis
neutrophil count
  • 0 views
  • 24 Jan, 2021
Microvesicles and Monocytes to Predict Mortality of Patients With Cirrhosis (PROMICE)

Chronic liver diseases related to viral hepatitis, metabolic syndrome or excessive alcohol consumption can evolve towards cirrhosis. Cirrhosis is responsible for 170 000 deaths per year in Europe. Initially asymptomatic and called "compensated" it can become "decompensated" with the developement of acute complications such as infections, ascites or variceal bleeding. …

biopsy of liver
liver disease
ascites
fibroscan
hypertension
  • 23 views
  • 03 May, 2022
  • 4 locations