Found 2598 clinical trials
INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors
This is a multicenter, open-label, dose-escalation/dose-expansion Phase 1 clinical study to investigate the safety, tolerability, PK profile, pharmacodynamics, and preliminary clinical efficacy of INCB106385 when given as monotherapy or in combination with INCMGA00012 in participants with selected CD8 T-cell-positive advanced solid tumors including SCCHN, NSCLC, ovarian cancer, CRPC, TNBC, bladder …
- 36 views
- 11 Jul, 2022
- 19 locations
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors
- 0 views
- 19 Jun, 2022
- 16 locations
TREATMENT OF LIVER FIBROSIS IN ADULTS WITH NONALCOHOLIC STEATOHEPATITIS (NASH)
NASH IS LIVER INFLAMMATION AND DAMAGE CAUSED BY A BUILDUP OF FAT IN THE LIVER.
- 142 views
- 03 Oct, 2019
- 1 location
AHEP0731: Combination Chemotherapy in Treating Young Patients with Newly Diagnosed Liver Cancer
AHEP0731: Combination Chemotherapy in Treating Young Patients with Newly Diagnosed Liver Cancer
- 440 views
- 07 Nov, 2020
- 1 location
C2541013 MIRNA NASH
is specifically designed to evaluate the effect of a range of doses of DGAT2i alone, and DGAT2i + ACCi, on resolution of NASH or improvement in liver fibrosis, as assessed histologically (via liver
- 1375 views
- 01 Oct, 2022
- 44 locations
Ascend-Nash: A Phase 2b, Randomized, Multi-Center, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Crv431 In Adult Subjects With Nonalcoholic Steatohepatitis And Advanced Liver Fibrosis
biopsy-proven nonalcoholic steatohepatitis (NASH) and stage 2 liver fibrosis (F2) / stage 3 liver fibrosis (F3).Exploratory:To validate the use of a composite NASH multi-omics AI-POWR™ biomarker
- 0 views
- 29 Sep, 2022
- 1 location
BLOOD SAMPLE COLLECTION- UNTREATED MELANOMA
MELANOMA, ALSO KNOWN AS MALIGNANT MELANOMA, IS A TYPE OF CANCER THAT DEVELOPS FROM THE PIGMENT-CONTAINING CELLS KNOWN AS MELANOCYTESUP OF FAT IN THE LIVER.
- 104 views
- 03 Oct, 2019
- 1 location
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
SLL Age greater than or equal to 18 years Not pregnant or breast-feeding women Adequate kidney and liver function Study Design:
- 169 views
- 15 Apr, 2019
- 1 location
A Research Study for Pentalogy of Cantrell
This study will collect blood, urine, and other tissue samples from patients with Pentalogy of Cantrell (POC) and other inherited diseases that may involve mutations in non-muscle myosin II-B heavy chain (MYH10). We will also collect samples from the relatives of affected individuals. POC is a very rare disorder in …
- 19 views
- 22 Dec, 2020
- 1 location
Fatty Liver Disease Research Study Enrolling
Fatty Liver Disease Research Study Enrolling
- 195 views
- 23 Nov, 2020
- 1 location