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Found 7 clinical trials
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A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

marrow and lymph node biopsies Participants should avoid grapefruit, Seville oranges, and grapefruit juice during the study. They also should avoid any live vaccines.

lymphoma
ibrutinib
chronic lymphocytic leukemia
monoclonal antibodies
anemia
  • 69 views
  • 15 Apr, 2019
  • 1 location
featured
A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 and Upadacitinib Given Alone or in Combination (ABBV-599 Combination) in Subjects with Moderately to Severely Active Systemic Lupus Erythematosus

The purpose of this study is to see if the study drugs, ABBV-105, upadacitinib (ABT-494), or both ABBV-105 and upadacitinib (ABT-494) in combination (ABBV-599) are safe, tolerable, and effective in treating your moderately to severely active systemic lupus erythematosus (SLE).  

cyclosporine
prednisone
  • 61 views
  • 23 Nov, 2020
  • 1 location
featured
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Multicenter Study Of Study Medicine On Peripheral Nerve Function In Patients With Osteoarthritis

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Multicenter Study Of Study Medicine On Peripheral Nerve Function In Patients With Osteoarthritis

  • 444 views
  • 08 Nov, 2020
  • 1 location
featured
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Investigational Product in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Investigational Product in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy

  • 156 views
  • 08 Nov, 2020
  • 1 location
Immunogenicity of Co-administered Oral Polio Vaccine and Oral Cholera Vaccine

Concomitant administration of multiple vaccines, including live attenuated immunizations, is safe and effective. Some restrictions apply for live vaccines; administering a live-virus vaccine

  • 5 views
  • 25 Feb, 2021
  • 1 location
Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients

Varicella is a vaccine-preventable disease, which can be severe in immunosuppressed children. Currently, the (live) vaccine is not recommended in pediatric orthotopic liver transplant recipients

vaccination
vaccine-preventable disease
liver transplant
immunosuppression
liver transplantation
  • 25 views
  • 26 Jan, 2021
  • 1 location
The Immunogenicity and Safety of Zostavax in Rheumatoid Arthritis Patients Using Abatacept

This investigator-initiated study will serve as a sub-study for the American College of Rheumatology-sponsored VERVE protocol currently funded by the NIH. This double-blinded multicenter randomized pragmatic trial is designed to determine whether Zostavax is safe and effective in patients with rheumatoid arthritis (RA) currently using anti-tumor necrosis factor (TNF) therapies. …

zostavax
zoster vaccine
anti-tnf-alpha therapy
tumor necrosis factor alpha
attenuated vaccine
  • 145 views
  • 23 Jan, 2021
  • 4 locations