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Found 12 clinical trials
Featured trial
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

marrow and lymph node biopsies Participants should avoid grapefruit, Seville oranges, and grapefruit juice during the study. They also should avoid any live vaccines.

fludarabine
night sweats
ibrutinib
anemia
lymphocytosis
  • 169 views
  • 15 Apr, 2019
  • 1 location
Featured trial
A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 and Upadacitinib Given Alone or in Combination (ABBV-599 Combination) in Subjects with Moderately to Severely Active Systemic Lupus Erythematosus

The purpose of this study is to see if the study drugs, ABBV-105, upadacitinib (ABT-494), or both ABBV-105 and upadacitinib (ABT-494) in combination (ABBV-599) are safe, tolerable, and effective in treating your moderately to severely active systemic lupus erythematosus (SLE).  

prednisone
cyclosporine
  • 155 views
  • 23 Nov, 2020
  • 1 location
Featured trial
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Multicenter Study Of Study Medicine On Peripheral Nerve Function In Patients With Osteoarthritis

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Multicenter Study Of Study Medicine On Peripheral Nerve Function In Patients With Osteoarthritis

  • 482 views
  • 08 Nov, 2020
  • 1 location
Featured trial
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Investigational Product in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Investigational Product in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy

  • 789 views
  • 08 Nov, 2020
  • 1 location
Immunogenicity of Co-administered Oral Polio Vaccine and Oral Cholera Vaccine

Concomitant administration of multiple vaccines, including live attenuated immunizations, is safe and effective. Some restrictions apply for live vaccines; administering a live-virus vaccine

Accepts healthy volunteers
  • 5 views
  • 19 Apr, 2022
  • 1 location
Measles and BCG Vaccines for Mother and Child

In Africa, the mortality from infectious diseases remains high. The investigators have discovered that live vaccines such as the BCG vaccine against tuberculosis and the measles vaccine can

  • 0 views
  • 03 Jun, 2021
  • 1 location
Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients (VZVinOLTx)

Varicella is a vaccine-preventable disease, which can be severe in immunosuppressed children. Currently, the (live) vaccine is not recommended in pediatric orthotopic liver transplant recipients

liver transplant
liver transplantation
immunosuppression
vaccine-preventable disease
vaccination
  • 25 views
  • 23 Jan, 2022
  • 1 location
Multiple Myeloma Trial of Orally Administered Salmonella Based Survivin Vaccine

Multiple myeloma patients will receive a cancer vaccine, called TXSVN that has been derived from the bacteria Salmonella. TXSVN is a weakened form of a live vaccine strain of the Salmonella

cancer
  • 0 views
  • 28 Oct, 2021
  • 1 location
The Immunogenicity and Safety of Zostavax® in Rheumatoid Arthritis Patients Using Abatacept (BMS-188667)

This investigator-initiated study will serve as a sub-study for the American College of Rheumatology-sponsored VERVE protocol currently funded by the NIH. This double-blinded multicenter randomized pragmatic trial is designed to determine whether Zostavax or Shingrix are safe and effective in patients with rheumatoid arthritis (RA) currently using anti-tumor necrosis factor …

anti-tnf-alpha therapy
ovariectomy
attenuated vaccine
tumor necrosis factor
varicella
  • 157 views
  • 01 May, 2022
  • 3 locations
Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients

Pediatric cancer survivors have increased infection-related morbidity and mortality. This study will evaluate immune dysfunction following cancer directed systemic therapy completion, with attention to clinical relevance and infection rate in this population compared to healthy siblings, when applicable. The investigators will also restart vaccinations at earlier time points than previously …

  • 0 views
  • 27 May, 2022
  • 1 location