Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 114 clinical trials
Liquid Biopsy-based Detection of Resistance to Targeted Therapy in Prostate Cancer Patients (PEARL)

This study will prospectively compare liquid-biopsy based methods for prediction of resistance under androgen-receptor signaling inhibitors. The main goal is to determine the optimal method to

surgical castration
bone lesions
progressive disease
testosterone
bone scan
  • 1 views
  • 09 May, 2022
  • 1 location
Early Detection of Gastric Cancer Using Plasma Cell-free DNA Fragmentomics

The purpose of this study is to enable non-invasive early detection of gastric cancer in high-risk populations through the establishment of a multimodal machine learning model using plasma cell-free DNA fragmentomics. Plasma cell-free DNA from early stage gastric cancer patients and healthy individuals will be subjected to whole-genome sequencing. Features, …

Accepts healthy volunteers
  • 0 views
  • 20 Jun, 2022
  • 1 location
ProSpecTive sAmpling in dRiver muTation Pulmonary Oncology Patients on Tyrosine Kinase Inhibitors (START-TKI) (START-TKI)

The study is perfomed with adult patients with non-small cell lung cancer treated with tyrosine kinase inhibitor. The objective is to collect repeated samples of blood from patients (starting) on a tyrosine kinase inhibitor, for liquid mutation testing, and pharmacokinetic analysis.

kinase inhibitor
lung carcinoma
tyrosine
  • 0 views
  • 21 Mar, 2022
  • 1 location
Host DNA Methylation for Endometrial Cancer Screening

Based on the previous study of NCT04651738, we performed this trial to further confirm the accuracy of host DNA CDO1 and CELF4 methylation for endometrial cancer screening in a multi-center cohort. Thirteen hospitals, including Peking Union Medical College Hospital, would enroll eligible patients in this study. The cervical cytology of …

cancer
hysterectomy
  • 0 views
  • 09 Apr, 2022
  • 1 location
Early Detection of Four Common Cancers Using the ctDNA Analysing Test (K-DETEK)

This is a multi-centre, prospective cohort study, aiming to evaluate a blood test in early detection of the four common cancers, based on the investigation of the circulating tumour DNA (ctDNA). Primary objective: To evaluate the performance characteristics of the blood ctDNA test in early detecting cancers. Secondary objectives: To …

Accepts healthy volunteers
  • 0 views
  • 16 May, 2022
  • 1 location
RB Liquid Biopsy Biorepository

Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed. Given this limitation, we use aqueous humor (AH), the clear fluid in …

bilateral retinoblastoma
cancer
  • 0 views
  • 19 Jul, 2021
  • 1 location
Pan-canceR Early-Stage deteCtion by lIquid Biopsy tEchNique projecT

PRESCIENT is a multi-center, prospective observational study aimed to detect cancers early by combined assays for serum protein markers and cell-free DNA (cfDNA) methylation markers. Blood RNA markers will also be evaluated. The study will enroll approximately 11879 participants, including participants with malignancies or benign diseases, and healthy participants.

primary cancer
  • 0 views
  • 10 Jun, 2021
  • 1 location
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and …

lung carcinoma
endometrioid carcinoma
pancreatic adenocarcinoma
endometrioid adenocarcinoma
cancer
  • 0 views
  • 04 Oct, 2021
  • 1 location
Liquid Biopsy Evaluation and Repository Development at Princess Margaret (LIBERATE)

The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for

cancer diagnosis
cancer
cfdna
tumor progression
primary cancer
  • 171 views
  • 05 May, 2022
  • 1 location
Augsburg Longitudinal Plasma Study for the Evaluation of Liquid Biopsy as Diagnostic Tool. (ALPS)

A prospective observational trial of patients with metastatic cancer of various entities which aims at both clarifying the significance of liquid biopsy and establishing a foundation for

cancer
  • 0 views
  • 22 Mar, 2022
  • 1 location