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Found 109 clinical trials
CAPRI 2 GOIM Study: Investigate the Efficacy and Safety of a Bio-marker Driven Cetuximab-based Treatment Regimen

third line) in a prospective fashion in each patient by liquid biopsy assessment of RAS/BRAF status.

  • 0 views
  • 27 Apr, 2022
  • 2 locations
Re-challenge Therapy With Chemotherapy & Panitumumab in Metastatic Colorectal Cancer Patients Treated With an Anti-EGFR (REPAN)

patients with metastatic colorectal cancer who were initially RAS wild and failed at least 2 lines of chemotherapy will be enrolled. Anti-EGFR must have been given in 1st line. Those who remain RAS-wild upon retesting will receive rechallenge with panitumumab and chemotherapy

EGFR
adenocarcinoma of colon
cetuximab
irinotecan
measurable disease
  • 7 views
  • 22 Apr, 2022
  • 1 location
Omic Technologies to Track Resistance to Palbociclib in Metastatic Breast Cancer

This is a monocentric cohort study, prospective and interventional with minimal risks and constraints for advanced breast cancer. The planned interventions are collection of biological samples at different times. The study will aim to do a descriptive analysis of omics profiles evolution (tumor, volatile organic components) over time, before and …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Liquid Biopsies for the Personalized Management of Patients With Hereditary Diffuse Gastric Cancer

Activating somatic mutations and methylation profiles identified by liquid biopsies could identify CDH1 and CTNNA1 pathogenic variants carriers with invasive diffuse gastric cancer undetectable by upper G-I endoscopy.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Implementing Circulating Tumor DNA Analysis at Initial Diagnosis to Improve Management of Advanced NSCLC Patients (CIRCULAR)

Multicenter prospective cohort study aiming to evaluate the detection rate of EGFR gene mutation in patients with advanced NSCLC in a real-word clinical setting, based on liquid biopsy and

lung carcinoma
carcinoma
liquid biopsy
EGFR
  • 0 views
  • 24 Mar, 2022
  • 1 location
Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening (ICRG0101)

The purpose of this study is to validate the interest of broadband spectroscopy analysis (femto/attosecond by infrared laser) on liquid biopsies in breast cancer screening.

Accepts healthy volunteers
  • 0 views
  • 23 Apr, 2022
  • 5 locations
Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis (CANWATCH)

Adjuvant chemotherapy was unnecessary in pathological stage Ⅱ colorectal cancer following initial treatment of surgery without high risk factors of recurrences. The treatment efficacy of adjuvant chemotherapy for pT1-3N0M0 colorectal cancer following preoperational chemotherapy or chemoradiotherapy remains unclear. Part of clinical local advanced colorectal cancer(cTxN1-2M0), which turn out to be …

chemotherapy regimen
adjuvant chemotherapy
cancer
adenocarcinoma
  • 0 views
  • 21 Mar, 2022
  • 1 location
Analysis of Circulating Tumor Markers in Blood (ALCINA 2)

The circulating tumoral biomarkers in the blood are the object of numerous researches for several decades. The potential clinical interests of these circulating biomarkers are diagnostic, prognostic, predictive of the efficiency of targeted therapies (according to the mutational profile of the cancer), and could allow the study of the mechanisms …

tumor markers
primary cancer
  • 2 views
  • 12 Feb, 2022
  • 2 locations
BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial

Background Accessing brain tumor material for pathological diagnosis requires invasive procedures that carry risk to patients including brain hemorrhages and death. Liquid biopsies are emerging non-invasive alternatives to direct tumour biopsies but the abundance of circulating tumor DNA (ctDNA) is relatively low and this limits our ability to accurately make …

  • 0 views
  • 18 Jul, 2021
  • 1 location
Cell-free DNA Methylation for Epithelial Ovarian Cancer

Liquid biopsy is challenging for the diagnosis of epithelial ovarian cancer (EOC). In this study, we performed the methylation testing of host DNA, namely, OPCML, FODX3 and CDH13, in the

  • 0 views
  • 27 Jan, 2021
  • 1 location