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Found 43 clinical trials
Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism (Test2Func)

The epidemics of obesity, MeTSy, T2DM and CVD are increasing worldwide. Non-alcoholic fatty liver disease (NAFLD) is becoming recognized as a condition possibly involved in the pathogenesis of these diseases. The prevailing hypothesis for NAFLD pathogenesis is the 'two-hit' model, with insulin resistance and hyperinsulinemia playing essential roles, which have …

  • 02 May, 2022
INTERVAL - Intense Exercise Trial for Men With Metastatic Castrate-Resistant Prostate Cancer

Exercise has been established to be safe and result in improved physical function and quality of life for most individuals with cancer. However, little information exists regarding whether exercise can increase overall survival and reduce disease progression, events related to cancer spreading to the bones (e.g. bone fracture, spinal cord …

bone metastases
metastatic prostate cancer
serum testosterone
  • 25 Jan, 2021
  • 4 locations
Ezetimibe Utilization Early After Acute Myocardial Infarction "EzAMI Trial"

Rationale Patients with acute coronary syndromes are at an increased risk for recurrent adverse coronary events, particularly during the early period following their initial presentation. Early (in-hospital) initiation of high-intensity statins reduces the risk of recurrent events and is therefore recommended by the best current practice guidelines.(1,2) However, the delayed …

myocardial infarction
combination therapy
hmg-coa reductase inhibitors
statin therapy
  • 06 Aug, 2021
  • 1 location
HoFH the International Clinical Collaborators Registry

-density lipoprotein cholesterol (LDL-C) from birth and premature atherosclerotic cardiovascular disease (ASCVD). Our current knowledge about HoFH is disjointed and largely stems from relatively small case

  • 25 Jun, 2021
  • 4 locations
EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Familial hypercholesterolaemia (FH) is a common genetic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C). If untreated, lifelong exposure to elevated LDL-C

early diagnosis
cholesterol level
lipoprotein cholesterol
low density lipoprotein
  • 27 Feb, 2022
  • 1 location
Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®

Protein convertase subtilisin kexin type 9 (PCSK-9) inhibitors demonstrated efficacy in cholesterol reduction and in the prevention of cardiovascular events. The investigators will evaluate changes in lipid profile, oxidation markers and subclinical atherosclerosis in patients with familial hypercholesterolemia (FH) during 12 weeks of treatment with a PCSK-9 inhibitor, Evolocumab.

cholesterol level
  • 01 Mar, 2022
  • 1 location
Non-Interventional Observational Retrospective Study to Evaluate Doravirine Based-regimens in HIV Infected Aged Patients (DORAge). (DORAge)

The HIV-infected population is aging due to the success of combination antiretroviral therapy, which prolongs survival, as well as the growing number of newly diagnosed cases in adults 50 years old and over. This real-life, observational and retrospective study aims to evaluate the virological efficacy, toxicity and tolerability of Doravirine-based …

Accepts healthy volunteers
  • 24 Mar, 2022
Prognostic Impact of Physical Activity Patterns After Percutaneous Coronary Intervention (PIPAP Study) (PIPAP)

of daily steps after one year with reaching targets for systolic blood pressure, low-density lipoprotein cholesterol (LDL-C), body mass index (BMI) and glycated haemoglobin (HbA1c); 3) Comparison of

  • 26 May, 2022
  • 1 location
Nanshan Elderly Cohort Study (NECS)

Objective: The Nanshan Elderly Cohort Study (NECS) aims to investigate the nutritional, as well as other environmental and genetic factors of chronic diseases, such as cardio-metabolic diseases. Study design: NECS is a community-based prospective cohort study. Participants: About 10000-20000 apparently healthy residents, living in Nanshan Shenzhen (South China) for >5 …

chronic disease
renal function study
metabolic disorders
  • 04 Mar, 2022
  • 1 location
The Influence of Autophagy on Fatty Liver

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. It is not known why only some obese subjects develop NAFLD. In recent years, a growing body of evidence showed a crucial role of autophagy in in the regulation of liver fat storage. …

fatty liver
liver disease
  • 17 Feb, 2021
  • 1 location