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Found 21 clinical trials
Pilot Study of Raltegravir Lipodystrophy IISP

The substitution of raltegravir for the NRTIs will result in some reversal of the long term adverse effect of lipodystrophy (specifically peripheral lipoatrophy) that is associated with

lipodystrophy
raltegravir
haart
  • 34 views
  • 08 Nov, 2020
  • 1 location
Immunogenicity of Metreleptin in Patients With Generalized Lipodystrophy

lipodystrophy (MYALEPT Prescribing Information). This study is a multicenter, open-label, Phase 4 trial to provide an assessment of the immunogenicity associated with metreleptin and of any major potential

  • 8 views
  • 24 Jan, 2021
  • 8 locations
Phase 2 Study of Obeticholic Acid for Lipodystrophy Patients

Lipodystrophies are rare disorders characterized by selective loss of adipose tissue and predisposition to insulin resistance and its metabolic complications. Hepatic steatosis is a common

  • 2 views
  • 26 Jan, 2021
  • 2 locations
SHARE: Simple HAART With Abacavir Reyataz and Epivir

SHARE: Simple HAART with Abacavir, Reyataz, and Epivir

atazanavir
antiretrovirals
haart
ritonavir
norvir
  • 8 views
  • 07 Nov, 2020
  • 1 location
Cyclophosphamide in the Treatment of Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes

This study evaluates the change of insulin resistance and glucose metabolism of patients with panniculitis associated acquired lipodystrophy syndrome and type 1 diabetes with the treatment of

  • 0 views
  • 19 Mar, 2021
  • 1 location
Body Composition and Adipose Tissue in HIV

In this study, the investigators will examine the effect of therapy with the Growth Hormone Releasing Hormone (GHRH) analog tesamorelin on body composition in patients with HIV lipodystrophy and

anti-retroviral therapy
growth hormone releasing hormone
insulin sensitivity
tesamorelin
fats
  • 28 views
  • 22 Jan, 2021
A Extension Study of Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance ( EMPIRE-02 )

A multicenter, open-label, single-arm, extension study with regard to the safety and efficacy of empagliflozin in patients with refractory diabetes mellitus with insulin resistance.

insulin
diabetes
insulin resistance
  • 0 views
  • 16 Mar, 2021
  • 5 locations
A Study of Baricitinib (LY3009104) in Adult and Pediatric Japanese Participants With NNS/CANDLE SAVI and AGS

dermatosis with lipodystrophy and elevated temperature (NNS/CANDLE), STING-associated vasculopathy with onset during infancy (SAVI), and Aicardi-Goutires Syndrome (AGS).

  • 0 views
  • 09 May, 2021
  • 5 locations
Contribution of Dolutegravir to Obesity and Cardiovascular Disease

The goal of the study is to combine a collaborative and translational approach to evaluate the effect antiretroviral regimen switch to a dolutegravir containing regimen compared to continued treatment with a non- dolutegravir based regimen on on lipid and metabolic profiles, renal function, body composition, vascular function and diet.

  • 0 views
  • 02 Feb, 2021
  • 1 location
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)

Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target …

myocardial infarction
cholesterol level
glycosylated hemoglobin
HIV Vaccine
peripheral artery disease
  • 17 views
  • 24 Mar, 2021
  • 1 location