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Found 37 clinical trials
Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency (AGL12)

Lipoprotein lipase (LPL) is an enzyme that plays an important role in removing triglycerides (TG) (molecules that transport dietary fat) from the blood. Patients with LPL deficiency (LPLD

lipase
fasting
hba1c
heparin
Accepts healthy volunteers
  • 9 views
  • 23 May, 2022
  • 1 location
Efficacy and Safety of Evinacumab in Adult Patients With Severe Hypertriglyceridemia for the Prevention of Recurrent Acute Pancreatitis

) mutations in lipoprotein lipase (LPL), and a history of hypertriglyceridemia (HTG)-associated acute pancreatitis (AP) who experience a recurrent episode of AP after treatment with evinacumab versus placebo

lipid-lowering therapy
body mass index
fasting
pancreatitis
  • 2 views
  • 13 May, 2022
  • 27 locations
Postprandial VLDL-triglyceride Metabolism in Type 2 Diabetes Patients With and Without NAFLD

lipoprotein lipase (LPL) mediated peripheral clearance. A recent study demonstrated that the ability of insulin to suppress hepatic VLDL-TG after a fat-enriched meal and the duration of the postprandial

  • 0 views
  • 03 Jun, 2022
A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB

Children with inadequate intestinal absorption due to loss of large amounts of small bowel require intravenous nutrition (feeding through the vein) to sustain hydration and nutrition to avoid starvation and dehydration; however, intravenous (IV) nutrition can lead to complications including liver failure. Tube feeding directly to the small intestine avoids …

gastrointestinal disease
direct bilirubin
intestinal resection
total bilirubin
small intestine
  • 0 views
  • 09 Feb, 2022
  • 1 location
Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma (GlitIpNi)

Phase I clinical trial on intra-tumoral ipilimumab plus intravenous nivolumab following the resection of recurrent glioblastoma. The aim of this clinical trial is to exploit the potential synergy of combined intra-tumoral CTLA-4 and systemic PD-1 blockade while minimizing the risk for increased immune-related toxicity by intratumoral administration of the CTLA-blocking …

neutrophil count
MRI
blood transfusion
temozolomide
recurrent glioblastoma
  • 146 views
  • 25 Feb, 2022
  • 1 location
DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas

Diagnostic tools are needed to identify mucinous cysts for further evaluation or follow-up respectively to identify cysts with HGD or invasive cancer at an early stage for surgical resection. Molecular genetic analysis of pancreatic cyst fluid is a new but rapidly evolving method to identify KRAS/GNAS oncogenic driver mutations in …

carcinoma
pancreatic neoplasm
KRAS
cancer
cyst
  • 0 views
  • 02 Mar, 2022
  • 1 location
Sofosbuvir/Velpatasvir Treatment of Chronic Hepatitis C During Pregnancy (STORC)

This is a multicenter, single arm study of Sofosbuvir/Velpatasvir (SOF/VEL) for treatment of chronic hepatitis C infection during pregnancy. Treatment will be initiated during the second or third trimester in approximately 100 pregnant people. Maternal participants will take one SOF/VEL tablet once daily for 12 weeks (84 days) and followed …

  • 0 views
  • 06 May, 2022
  • 1 location
Effects of Microbial Enzyme Supplementation on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Middle-Aged and Older Adults (BIO-3003)

The primary objective of this study is to investigate the acute effects of a microbial multi-enzyme mixture ("BC-006") on postprandial nutrient levels in healthy, middle-aged to older adults during a mixed meal tolerance test. Additionally, the effects of twice daily consumption of BC-006 and placebo for 3 weeks on abdominal …

Accepts healthy volunteers
  • 0 views
  • 22 Mar, 2022
  • 1 location
High Fat Meal and Postprandial TG Levels With and Without Exercise Intervention

The objective of this study is to investigate whether "real-life" bouts of MIE are effective at attenuating PPTL after a meal (either a keto-type brownie (KETO) or a high carb (CON) meal of pasta and sauce), compared to non-exercise control. The primary outcome of this study is the measured change …

Accepts healthy volunteers
  • 0 views
  • 19 Apr, 2022
  • 1 location
Regular vs. Clear Liquid Diet for Mild to Moderate Acute Pancreatitis

Acute pancreatitis is among the most common gastroenterology diagnosis in the United States, and represents a large economic burden to the United States health system. While recent guidelines agree early feeding shortens length of stay, these guidelines fail to provide recommendations on optimal diet to start leaving diet type to …

Accepts healthy volunteers
lipase
acute pancreatitis
abdominal pain
amylase
  • 0 views
  • 27 Dec, 2021
  • 1 location