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Found 20 clinical trials
Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline Delamanid and Linezolid) With the Current South African Standard of Care

of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) and clofazimine (CFZ) compared to the current South African Standard of Care (Control Strategy) for 9 months for

susceptibility testing
delamanid
bedaquiline
rifampin
levofloxacin
  • 0 views
  • 16 Oct, 2021
  • 1 location
Modified BPaL Regimen for Managing Pre-XDR TB and MDR (TI/NR) TB in India

> Need for shorter, tolerable and effective regimen Hence modified BPaL regimen is designed to study the newer shorter oral in varying doses of Linezolid for pre XDR Tb patients and MDR TI

  • 0 views
  • 17 Nov, 2021
  • 1 location
Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD).

indicated in CNS infections (vancomycin, daptomycin, ceftazidime, meropenem, colistin, linezolid, piperacillin-tazobactam and ceftaroline) and to study the Cefepime diffusion in the CSF, known to be highly

  • 0 views
  • 16 Feb, 2022
  • 1 location
Randomized Controlled Multi-center Short Course Treatment for Rifampicin Resistant Tuberculosis

This study is a randomized, controlled, multi-center clinical study. The main purpose of this study was to study the efficacy and safety data of total oral short-term therapy as an alternative to injection in the treatment of newly diagnosed RR-TB patients.

  • 4 views
  • 25 Jan, 2021
  • 1 location
Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis

Antimicrobial treatment could be beneficial in patients with ventilator-associated tracheobronchitis (VAT). The hypothesis of this study is that antibiotic treatment for VAT (3 or 7 days), compared with no antibiotic treatment, would reduce the incidence of transition from VAT to ventilator-associated pneumonia (VAP).

pneumonia
tracheobronchitis
antibiotics
invasive mechanical ventilation
imipenem
  • 0 views
  • 24 Jan, 2021
  • 1 location
Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

Because of its prolonged terminal half-life, dalbavancin is an extremely attractive option in treating Gram-positive infections caused by S. aureus including MRSA, and streptococcal species. Systemic bacterial infections due to Staphylococci such as osteomyelitis and septic arthritis, are conditions which require prolonged IV therapy, typically for at least 3-6 weeks, …

dalbavancin
methicillin
prosthetic shoulder
staphylococcus aureus
ortho evra
  • 227 views
  • 26 Feb, 2022
  • 1 location
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections

The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the development of antibiotic resistance. The project aims are: (i) To improve the current diagnostic approaches and …

  • 0 views
  • 29 Aug, 2021
  • 1 location
Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis-PandrTB Tuberculosis (PandrTB)

PandrTB is a study of the pharmacokinetics(PK) and pharmacodynamics(PD) of bedaquiline, delamanid, clofazimine, linezolid, moxifloxacin, levofloxacin and pyrazinamide used in novel combinations

delamanid
bedaquiline
levofloxacin
combinations
linezolid
  • 0 views
  • 03 Mar, 2022
  • 4 locations
Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions

Linezolid is the second line agent in the treatment of MRSA and PRSP infections, and it is also the drug of choice for VRE infections. It can be an alternative option against multidrug resistant

tuberculosis
neuropathy
  • 46 views
  • 23 Mar, 2022
  • 1 location
Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance

The investigator's purpose is to study the population pharmacokinetics of commonly used antimicrobial agents in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility.

  • 0 views
  • 21 Apr, 2021
  • 1 location