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Found 20 clinical trials
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis

(TBM) in adolescents and adults with or without HIV-infection in sub-Saharan Africa: Intensified TBM treatment with high-dose rifampicin and linezolid, compared to WHO standard TBM

  • 0 views
  • 24 Feb, 2021
  • 12 locations
Adjunctive Linezolid for the Treatment of Tuberculous Meningitis

This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at

  • 0 views
  • 17 Jun, 2021
  • 1 location
Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB (DRAMATIC)

, the investigators will examine the efficacy and safety of an all-oral regimen of bedaquiline, delamanid, levofloxacin, linezolid, and clofazimine given for 16, 24, 32 or 40 weeks

  • 0 views
  • 12 May, 2022
  • 1 location
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)-PLUS

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of bedaquiline, linezolid, cycloserine, clofazimine and pyrazinamide treatments guided by PZA

  • 0 views
  • 29 Jan, 2021
  • 15 locations
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to

clofazimine
smear
rifampin
pyrazinamide
linezolid
  • 0 views
  • 24 Jan, 2021
  • 13 locations
Patient-reported Experiences and Quality of Life Outcomes in the TB-PRACTECAL Clinical Trial

PRACTECAL-PRO is a sub-study of a TB-PRACTECAL clinical trial for multidrug resistant Tuberculosis. It evaluates the effectiveness of TB-PRACTECAL interventions from the patient perspective in terms of their quality of life, shared decision making and satisfaction with services.

moxifloxacin
bedaquiline
clofazimine
linezolid
pretomanid
  • 2 views
  • 24 May, 2021
  • 7 locations
Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q) (endTB-Q)

endTB-Q Clinical Trial is a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of two new, all-oral, shortened regimens for multidrug-resistant tuberculosis (MDR-TB) with fluoroquinolone resistance.

fluoroquinolones
clofazimine
vasectomy
pulmonary tuberculosis
bedaquiline
  • 94 views
  • 11 Mar, 2022
  • 7 locations
Pharmacokinetic Study of Linezolid for TB Meningitis

conversion in African pulmonary TB patients. Next to a higher dose of rifampicin, the approved antibacterial drug linezolid seems a good candidate for a new TBM regimen. The drug penetrates well into

  • 0 views
  • 06 May, 2021
  • 1 location
Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline Delamanid and Linezolid) With the Current South African Standard of Care

of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) and clofazimine (CFZ) compared to the current South African Standard of Care (Control Strategy) for 9 months for

treatment regimen
clofazimine
ethambutol
pyrazinamide
linezolid oral tablet
  • 0 views
  • 16 Oct, 2021
  • 1 location
Alternative Antibiotics for Syphilis

The Trep-AB clinical trial will test the efficacy of an investigational neuropenetrative drug, Linezolid (LZD), compared to standard treatment, Benzathine penicillin G (BPG), for early syphilis

  • 0 views
  • 24 Nov, 2021
  • 3 locations