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Found 65 clinical trials
Saliva and Extracellular Vesicles for Parkinson's Disease (RaSPiD)

Rehabilitation is crucial in the treatment of people with Parkinson's disease (PD) as it can ameliorate motor and non-motor impairments, improving their clinical profile and quality of life. Considering the complex biological processes occurring in PD brain, the identification of accessible and measurable biomarkers to monitor the events induced by …

Accepts healthy volunteers
  • 0 views
  • 21 Apr, 2022
PUMCH Dementia Longitudinal Cohort Study

The PUMCH Dementia Cohort is a hospital-based, observational study of Chinese elderly with cognitive impairment.

cognitive impairment
dementia
Accepts healthy volunteers
  • 0 views
  • 26 Jan, 2022
  • 1 location
Exploring Biomarkers in Age Stratified PUMCH Dementia Cohort

Biomarkers are important for early and precise diagnosis of dementia. However, the causes of dementia in different age are different. We designed an age stratified dementia cohort and tried to explore biomarkers of different groups of dementia, incorporating neuropsychology, multi-model neuroimaging, metabolics and proteomics based fluid biomarkers as well as …

dementia
Accepts healthy volunteers
  • 0 views
  • 26 Jan, 2022
  • 1 location
Natural History Study of Synucleinopathies

frequently diagnosed with Parkinson disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA). However, accumulation of alpha-synuclein and death of nerve cells can also begin

parkinson's disease
orthostatic hypotension
atrophy
lewy body disease
multiple system atrophy
  • 768 views
  • 25 Jan, 2022
  • 8 locations
Cerebro Spinal Fluid Collection (CSF) (Analzheimer)

Cognitive neurodegenerative diseases are a major public health issue. At present, the diagnosis of certainty is still based on anatomopathological analyses. Even if the diagnostic tools available to clinicians have made it possible to improve probabilistic diagnosis during the patient's lifetime, there are still too many diagnostic errors and sub-diagnostic …

early diagnosis
dementia
alzheimer's disease
neurodegenerative disorder
  • 0 views
  • 25 Jan, 2022
Modifiable Variables in Parkinsonism (MVP)

We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD symptoms, and reduced rates of progression. After agreeing to participate, we will ask participants …

parkinson's disease
atrophy
corticobasal degeneration
dementia
parkinsonism
  • 282 views
  • 05 Apr, 2022
  • 1 location
UPenn Observational Research Repository on Neurodegenerative Disease (UNICORN)

The aim of this study is to create a repository of both cross-sectional and longitudinal data, including cognitive, linguistic, imaging and biofluid biological specimens, for neurodegenerative disease research and treatment.

parkinson's disease
atrophy
dementia, frontotemporal
progressive supranuclear palsy
Accepts healthy volunteers
  • 1 views
  • 25 Mar, 2022
  • 1 location
The China Longitudinal Aging Study of Cognitive Impairment

Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early …

nervousness
vascular dementia
cognitive disorder
brain imaging
cognitive impairment
  • 142 views
  • 14 Feb, 2022
  • 1 location
Genetic Characterization of Movement Disorders and Dementias

Background There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes. On the other hand, dementia is a condition of declining mental abilities, especially memory. Dementia can occur at any age but …

heart disease
genetic testing
movement disorder
cognitive impairment
Accepts healthy volunteers
  • 655 views
  • 19 Jun, 2022
  • 1 location
The Sunnybrook Dementia Study (SDS)

therapies. Over 1300 patients (Mild Cognitive Impairment or dementia from AD, Vascular, Frontotemporal or Lewy Body Disease) and 140 normal elderly have already been enrolled, with 180 autopsies.

demented
neurodegenerative disorders
neuropsychological test
cognitive impairment
Accepts healthy volunteers
  • 19 views
  • 26 May, 2022
  • 1 location