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Found 65 clinical trials
ATH-1017 Treatment in Subjects With Parkinson's Disease Dementia or Dementia With Lewy Bodies (SHAPE Trial)

This study is designed to evaluate the safety and treatment effects of fosgonimeton (ATH-1017) in subjects with Parkinson's Disease Dementia or Dementia with Lewy Bodies, with a randomized

parkinson's disease
dementia
  • 0 views
  • 07 Jun, 2022
  • 10 locations
Trial of Ondansetron as a Parkinson's HAllucinations Treatment (TOP HAT)

TOPHAT (Trial of Ondansetron as a Parkinson's HAllucinations Treatment) is a double blind, individually randomized, placebo-controlled, parallel group, flexible dose trial of ondansetron (8-24mg/day) as a treatment for Parkinson's hallucinations, with a 12-week primary outcome and follow-up to 24 weeks.

antipsychotic agents
visual hallucinations
parkinson's disease
hallucinations
cholinesterase
  • 0 views
  • 17 May, 2022
  • 19 locations
Stimulation of Cingulao-opercular Alertness Network (SCAN)

Fluctuations in alertness are very common in persons with Lewy body dementias and are a major source of disability. Changes in a chemical messenger molecule called acetylcholine within certain brain regions may play a role in these fluctuations. We propose to test this hypothesis and also determine whether a non-invasive …

depression
cognitive symptoms
behavioral symptoms
visual hallucinations
vascular dementia
  • 0 views
  • 25 Jan, 2022
  • 1 location
Self and Autobiographical Memory in Dementia With Lewy Bodies and Alzheimer Disease: a Behavioral and Multimodal Neuroimaging Study (SELF-MCL)

The present project aims at exploring different components of Self-consciousness or 'the Self', such as autobiographical memory, self-concept and subjective sense of Self, in dementia with Lewy

cognitive assessment
Accepts healthy volunteers
mild dementia
cognitive impairment
dementia
  • 0 views
  • 25 Jan, 2022
  • 1 location
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)

A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia

parkinson's disease
cognitive impairment
dementia
mild dementia
mild cognitive impairment
  • 635 views
  • 16 Jun, 2022
  • 25 locations
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment (OCTAVO)

Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases. These retinal anomalies objectified by OCT-A (Optical coherence tomography …

cognitive disorder
optical coherence tomography
neurodegenerative disorder
Accepts healthy volunteers
neurodegenerative disorders
  • 28 views
  • 25 Jan, 2022
  • 1 location
[18F]F-DOPA Imaging in Patients With Autonomic Failure

), Multiple System Atrophy (MSA), Dementia with Lewy Bodies (DLB). Common to these disorders are the involvement of the central and peripheral autonomic nervous system, where Pure Autonomic Failure (PAF) is

dopa
alpha-synuclein
synucleinopathy
parkinson's disease
carbidopa
  • 19 views
  • 01 May, 2022
  • 1 location
PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia

Caregivers of individuals with Alzheimer's disease and related dementia rarely get the preparation or training they need to manage their caregiving responsibilities and to successfully balance their own self-care and their caregiving roles. As a result, caregivers often experience caregiver burden, emotional distress, and substance abuse. Therefore, there is a …

Accepts healthy volunteers
dementia
alzheimer's disease
  • 2 views
  • 25 Jan, 2022
  • 2 locations
WeCareAdvisor Study for Caregivers of People Living With Dementia

The WeCareAdvisor is an online tool to help caregivers manage behavioral and psychological symptoms of people living with dementia. The trial will evaluate its efficacy to reduce caregiver distress, improve confidence managing behaviors, as well as reduce occurrences and severity of behavioral and psychological symptoms. Visit https://wecareadvisorstudy.com/ for more information.

depression
psychotropic
Accepts healthy volunteers
dementia
psychological symptoms
  • 0 views
  • 23 Mar, 2022
  • 1 location
Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers (RETEVAL)

Alzheimer disease is hard, long and expensive to diagnose. In order to help the clinician, a new biomarker in Alzheimer disease seems to be very useful. The retina, as a window of the brain, could offer a new way to diagnose this common disease. Indeed, a retinal atrophy could especially …

optical coherence tomography
Accepts healthy volunteers
mini-mental state examination
atrophy
  • 1 views
  • 25 Jan, 2022
  • 1 location