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Found 36 clinical trials
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis

The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment of TBM. The investigators will conduct a LTA4H genotype stratified, parallel group, randomised, double blind, placebo-controlled multi-centre Phase III non-inferiority trial …

corticosteroids
rifampin
tuberculosis treatment
tb chemotherapy
meningitis
  • 53 views
  • 26 Jan, 2021
  • 3 locations
Evaluating Newly Approved Drugs for Multidrug-resistant TB

endTB Clinical Trial a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of five new, all-oral, shortened regimens for multidrug-resistant tuberculosis (MDR-TB).

pyrazinamide
levofloxacin
clofazimine
moxifloxacin
vasectomy
  • 223 views
  • 20 Sep, 2021
  • 8 locations
Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.

The number of cardiac implantable electronic devices (CIEDs) implanted each year has grown rapidly over the past two decades. CIED infections, defined as infections involving the generator implant site (pocket) and/or intravascular leads, have become increasingly prevalent, with the rate of growth in infections outpacing that of CIED procedures. The …

corticosteroids
clindamycin
  • 0 views
  • 22 Aug, 2021
  • 1 location
Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant

Ciprofloxacin and levofloxacin are both in guidelines to use for prophylaxis in autologous and allogeneic Stem cell transplant.Ciprofloxacin was recently replaced by levofloxacin as the

  • 0 views
  • 27 Jan, 2021
  • 1 location
Levofloxacin Ocular Implant for Ocular Surgery

This is a multi center, open label, interventional study in one eye of 5 subjects scheduled for uncomplicated cataract surgery with administration of a single Levofloxacin Ocular Implant in the

  • 0 views
  • 18 Jul, 2021
  • 3 locations
The Pharmacokinetics of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5%

been taken to reduce the incidence of post-operative endopthalmitis post-cataract surgery, this includes the use of pre-operative topical levofloxacin, intracameral cefuroxime, and providone iodine as

  • 0 views
  • 26 Jan, 2021
  • 2 locations
Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection

From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment

amoxicillin
levofloxacin
bismuth
antibiotic therapy
antibiotics
  • 0 views
  • 26 Mar, 2021
  • 1 location
Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors

The purpose of this study is to determine whether moxifloxacin in comparison to levofloxacin plus metronidazole are effective and safe in the treatment of community-acquired pneumonia

metronidazole
levofloxacin
cough
moxifloxacin
  • 5 views
  • 07 Nov, 2020
  • 1 location
Helicobacter Pylori First-line Treatment in Patients Allergic to Penicillin

The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment

tetracycline
tinidazole
levofloxacin
  • 1 views
  • 24 Jan, 2021
  • 1 location
Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline Delamanid and Linezolid) With the Current South African Standard of Care

of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) and clofazimine (CFZ) compared to the current South African Standard of Care (Control Strategy) for 9 months for

pyrazinamide
levofloxacin
ethambutol
clofazimine
susceptibility testing
  • 0 views
  • 24 Jan, 2021
  • 1 location