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Found 21 clinical trials
Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB (DRAMATIC)

, the investigators will examine the efficacy and safety of an all-oral regimen of bedaquiline, delamanid, levofloxacin, linezolid, and clofazimine given for 16, 24, 32 or 40 weeks

  • 0 views
  • 10 Jul, 2022
  • 1 location
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to

levofloxacin
smear
rifampin
linezolid
pyrazinamide
  • 0 views
  • 24 Jan, 2021
  • 13 locations
Effects of CKI for Oral Mucositis Caused by Radiotherapy for Head and Neck Cancer

Oral mucositis (OM) is an acute side effect of radiotherapy for head and neck cancer (HNC). OM associated pain affects oral functions and nutrition of the patient that may result in discontinuity of treatment.The purpose of this clinical study is to evaluate the therapeutic effects of Compound Kushen Injection (CKI) …

  • 2 views
  • 21 Feb, 2022
  • 12 locations
Antibiotics to Decrease Post ERCP Cholangitis

Endoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic procedure used to treat bile duct stones, obstructive jaundice, biliary leaks, and a variety of other conditions. There is active debate whether antibiotics should be given prophylactically for ERCP outside of high risk indications including primary sclerosing cholangitis. In part this is due …

  • 10 views
  • 25 Feb, 2022
  • 1 location
Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic Patients

This randomized controlled clinical trial will compare the eradication efficacy of bismuth quadruple therapy containing clarithromycin+metronidazole, clarithromycin+levofloxacin, or

  • 0 views
  • 22 Sep, 2021
  • 1 location
Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis (NEW-STRAT TB)

rifampicin and levofloxacin for 14 days in addition to standard TB therapy with or without steroids among adults hospitalized with HIV-associated disseminated tuberculosis. The investigators

  • 0 views
  • 23 Apr, 2022
  • 2 locations
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis

The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment of TBM. The investigators will conduct a LTA4H genotype stratified, parallel group, randomised, double blind, placebo-controlled multi-centre Phase III non-inferiority trial …

isoniazid
tuberculosis treatment
rifampin
tb chemotherapy
meningitis
  • 53 views
  • 28 Apr, 2022
  • 1 location
Helicobacter Pylori First-line Treatment in Patients Allergic to Penicillin

The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment

levofloxacin
tinidazole
tetracycline
  • 1 views
  • 27 Feb, 2022
  • 1 location
Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline Delamanid and Linezolid) With the Current South African Standard of Care

of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) and clofazimine (CFZ) compared to the current South African Standard of Care (Control Strategy) for 9 months for

isoniazid
treatment regimen
susceptibility testing
bedaquiline
linezolid
  • 0 views
  • 16 Oct, 2021
  • 1 location
Susceptibility Testing Guided Versus Empirical Therapy for Refractory H. Pylori Infection

test will be used to determine the minimum inhibitory concentrations of levofloxacin, tetracycline, rifabutin, and clarithromycin to guide the selection of antibiotics. Treatment regimens and

  • 0 views
  • 03 Feb, 2021
  • 1 location