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Found 61 clinical trials
Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning

Parkinson's disease (PD) is characterized by severe motor symptoms, including upper limb dysfunction, that is only partially alleviated by medication. PD is also a motor learning disease due to the degradation of the striatum, involved in the consolidation of motor memory. We showed earlier that motor practice improves writing deficits …

motor symptoms
  • 0 views
  • 19 Aug, 2021
  • 1 location
Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study

The gamma knife radiosurgical thalamotomy to treat many movement disorders is recently becoming a new and well defined treatment paradigm. The CyberKnife if compared to the frame-based radiosurgery, is a pain free procedure which offers the advantage of a better patient's compliance by avoiding local anaesthesia and the discomfort due …

  • 0 views
  • 24 Jan, 2021
  • 1 location
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease

The project intends to assess the polygenic burden of rare disruptive mutations in Parkinson's disease (PD) and how they influence the phenotype/pathological heterogeneity of disease.

resting tremor
tremor
dyskinesia
levodopa
dopa
  • 0 views
  • 16 Sep, 2021
  • 1 location
An Observational Study on Safinamide Rasagiline and Other Standard of Care in PD

The purpose of this study is to evaluate how safinamide, rasagiline and other SoC drugs are associated with the quality of life of PD patients by means of the Parkinson's Disease Questionnaire (PDQ)-39 items.

rasagiline
antiparkinsonian agents
levodopa
dopa
safinamide
  • 0 views
  • 19 Aug, 2021
  • 3 locations
Neurodegenerative Diseases Registry

With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian syndromes (PS), small vessel disease (SVD) and motor neuron disease (MND). In spite of the progress of knowing the pathogenesis …

atrophy
lewy body dementia
parkinsonism
drug trials
corticobasal degeneration
  • 36 views
  • 05 Aug, 2021
  • 1 location
Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors

In this study, the investigators will examine the association of statin use and dyskinesia in a convenience sample Parkinson's disease patients in the Veterans Administration Health Care System.

dyskinesia
levodopa
  • 2 views
  • 01 Mar, 2021
  • 3 locations
Opicapone Treatment Initiation Open-Label Study

This is an observational study to describe the treatment patterns and clinical outcomes observed with use of ONGENTYS as adjunctive treatment to levodopa/carbidopa in Parkinson's disease

  • 0 views
  • 29 Apr, 2021
  • 6 locations
Prognosis of Behavioral Addiction in Parkinson's Disease

/ or worsening of dyskinesia due to higher levodopa doses to compensate for the drop in behavioral addictions) and non-motor (withdrawal syndrome dopamine agonist) anxiously including apathy.

levodopa
dopamine
conventional treatment
dyskinesia
  • 15 views
  • 21 Jan, 2021
  • 1 location
Comparison of the Incidence of Dyskinesia in Parkinson's Disease Who Were Treated With Amantadine or Dopamine Agonist

The purpose of this study is to compare the onset time and severity of dyskinesia in amantadine or Dopamine agonist initial treated groups in Parkinson's disease.

amantadine
dopamine
dopamine agonists
dyskinesia
  • 1 views
  • 21 Jan, 2021
  • 1 location
Can Subthalamic Stimulation Using Directional Electrodes Improve Postoperative Management in Parkinson's Disease

The primary objective of the study is to determine if subthalamic nucleus (STN) deep brain stimulation (DBS) using the Vercise directional leads improves neuropsychiatric state and neuropsychiatric fluctuations 12 months after surgery in a large consecutive series of STN-DBS Parkinson's disease (PD) patients.

  • 0 views
  • 13 Aug, 2021
  • 4 locations