Found 61 clinical trials
Auricular Muscle Zone Stimulation for Parkinson Disease
A Multicenter, Randomized, Blinded, Electronic Device in Subjects with Parkison Disease.
- 0 views
- 12 Aug, 2021
- 9 locations
Impact of Nilotinib on Safety Tolerability Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies
Dementia with Lewy Bodies (DLB) is an alphasynucleinopathy and the second most common form of dementia in the elderly. DLB shares striking neuropathological and clinical similarities with both Parkinson's disease (PD) and Alzheimer's disease (AD). Nilotinib (Tasigna, AMN107, Novartis, Switzerland) is approved by the FDA and is well tolerated for …
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- 22 Aug, 2021
- 1 location
A Randomized Controlled Trial of Nicotinamide Supplementation in Early Parkinson's Disease
NOPARK is a double-blinded randomized controlled trial that studies nicotinamide supplementation in early Parkinson's disease. Parkinson's disease (PD) is a major cause of death and disability and has a worldwide socioeconomic impact. It affects ~2% of the population above the age of 65 years and its prevalence increases dramatically as …
- 20 views
- 24 Jan, 2021
- 8 locations
Predictive Value of Multimodal MRI in Parkinson's Disease
Deep brain stimulation (DBS) is recognized as the most safe and effective neurosurgical method for the treatment of advanced Parkinson's disease. However, the mechanism of relieving motor and non-motor symptoms of Parkinson's disease has not been fully clarified, and the prognosis is significantly different. This study is based on multimodal …
- 0 views
- 21 Aug, 2021
- 1 location
Aerobic Exercise and Brain Health in Parkinson's
The purpose of the project is to investigate how moderate to high intensity aerobic exercise affects brain health in patients with Parkinson's disease. Assessments include MRI, blood markers, cognition, functional tests, questionnaires, and cardiorespiratory fitness. The study will be a single blinded randomized controlled trial with a 6-month long intervention.
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- 12 Aug, 2021
- 1 location
PD-Ballet: Effectiveness and Implementation in Parkinson's Disease
Current literature consistently demonstrates beneficial motor effects of dance-based therapies in Parkinson's disease, along with improved quality of life. Little is known about the non-motor gains following such therapy. To date, no RTC has been conducted to investigate the benefits of ballet dancing in Parkinson's disease. The investigators aim to …
- 0 views
- 14 Jul, 2021
- 1 location
DBS and SCS Therapy Improve Motor Function in Multiple System Atrophy With Predominant Parkinsonism
Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder and symptomatic therapeutic strategies are still limited.The parkinsonian type of MSA (MSA-P) has parkinsonian symptoms as its prominent manifestation, although Deep brain stimulation (DBS) at the subthalamic nucleus or globus pallidus interna has been an established treatment for Parkinson's …
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- 30 Jan, 2021
- 1 location
Deep Brain Stimulation Therapy in Movement Disorders
Background In deep brain stimulation (DBS), a device called a neurostimulator is placed in the chest. It is attached to wires in parts of the brain that affect movement. DBS might help people with movement disorders like Parkinson s disease (PD), dystonia, and essential tremor (ET). Objective To provide DBS …
- 226 views
- 15 Sep, 2021
- 1 location
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease
The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD. The study has been powered to detect a clinically significant reduction in …
- 1 views
- 14 Jun, 2021
- 1 location
Motor Learning in Parkinson's Disease: Underlying Effective Connectivity and Influential Factors
Parkinson's disease (PD) is characterized by severe motor symptoms that can only be partially alleviated by medication. It was shown previously that rehabilitation is an important therapeutic supplement for micrographia in early disease. However, what is unknown is how motor learning impacts on the underlying neural networks in patients with …
- 0 views
- 16 Aug, 2021
- 1 location