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Found 56 clinical trials
PD-Ballet: Effectiveness and Implementation in Parkinson's Disease

Current literature consistently demonstrates beneficial motor effects of dance-based therapies in Parkinson's disease, along with improved quality of life. Little is known about the non-motor gains following such therapy. To date, no RTC has been conducted to investigate the benefits of ballet dancing in Parkinson's disease. The investigators aim to …

motor symptoms
  • 0 views
  • 25 Jan, 2022
  • 1 location
Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease (PDBIKE)

This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson's disease. The investigators will examine the efficacy of novel rehab technique that can be monitored and modified in real-time but over virtual interface using a …

antiparkinsonian agents
  • 0 views
  • 30 Apr, 2022
  • 1 location
DBS and SCS Therapy Improve Motor Function in Multiple System Atrophy With Predominant Parkinsonism

Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder and symptomatic therapeutic strategies are still limited.The parkinsonian type of MSA (MSA-P) has parkinsonian symptoms as its prominent manifestation, although Deep brain stimulation (DBS) at the subthalamic nucleus or globus pallidus interna has been an established treatment for Parkinson's …

  • 0 views
  • 30 Jan, 2021
  • 1 location
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease (TALISMAN-1)

In recent years, mitochondrial dysfunction and oxidative stress have been implicated in PD pathophysiology. Intermittent hypoxia therapy (IHT) is an upcoming treatment used by elite athletes as well as fragile individuals in clinical settings that works by improving exercise tolerance, neuroplasticity and inducing hypoxic preconditioning (HPC). HPC might improve the …

dopamine
movement disorder
  • 0 views
  • 12 May, 2022
  • 1 location
Deep Brain Stimulation Therapy in Movement Disorders

Background In deep brain stimulation (DBS), a device called a neurostimulator is placed in the chest. It is attached to wires in parts of the brain that affect movement. DBS might help people with movement disorders like Parkinson s disease (PD), dystonia, and essential tremor (ET). Objective To provide DBS …

dyskinesia
dystonia
tremor
electrocardiogram
essential tremor
  • 226 views
  • 09 Aug, 2022
  • 1 location
Motor Learning in Parkinson's Disease: Underlying Effective Connectivity and Influential Factors

Parkinson's disease (PD) is characterized by severe motor symptoms that can only be partially alleviated by medication. It was shown previously that rehabilitation is an important therapeutic supplement for micrographia in early disease. However, what is unknown is how motor learning impacts on the underlying neural networks in patients with …

mini-mental state examination
dementia
motor symptoms
Accepts healthy volunteers
mental state examination
  • 0 views
  • 27 Feb, 2022
  • 1 location
Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning

Parkinson's disease (PD) is characterized by severe motor symptoms, including upper limb dysfunction, that is only partially alleviated by medication. PD is also a motor learning disease due to the degradation of the striatum, involved in the consolidation of motor memory. We showed earlier that motor practice improves writing deficits …

motor symptoms
Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 1 location
ELEGANCE - A Non-interventional Study on Long-term Effectiveness and Safety of Levodopa-Entacapone-Carbidopa Intestinal Gel (Lecigon®) in Patients With Advanced Parkinson's Disease in Routine Care (ELEGANCE)

This observational study is designed to collect data on the use of the drug Lecigon® in daily clinical practice. The study is organised and funded by a pharmaceutical company called Britannia Pharmaceuticals Ltd (Britannia). Lecigon® is prescribed by physicians in advanced Parkinson's disease when patients suffer from uncontrollable fluctuations in …

  • 0 views
  • 19 Aug, 2022
  • 20 locations
An Observational Study on Safinamide, Rasagiline and Other Standard of Care in PD (SUCCESS)

The purpose of this study is to evaluate how safinamide, rasagiline and other SoC drugs are associated with the quality of life of PD patients by means of the Parkinson's Disease Questionnaire (PDQ)-39 items.

levodopa
safinamide
rasagiline
antiparkinsonian agents
dopa
  • 0 views
  • 05 Mar, 2022
  • 3 locations
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease

The project intends to assess the polygenic burden of rare disruptive mutations in Parkinson's disease (PD) and how they influence the phenotype/pathological heterogeneity of disease.

levodopa
dyskinesia
Accepts healthy volunteers
resting tremor
tremor
  • 0 views
  • 25 Jan, 2022
  • 1 location