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Found 61 clinical trials
Dopaminergic Mechanism of Memory Impairment in Parkinson's Disease

The cognitive impairment of Parkinson's disease is non amnestic, which is characterized by working memory impairment and executive dysfunction. The current drug therapy (such as levodopa

levodopa
selegiline
dopamine
cognitive impairment
  • 0 views
  • 13 Sep, 2021
  • 1 location
Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease With Constipation

PD, including levodopa and dopamine agonist, can also cause constipation. In recent years, an increasing number of studies have been conducted to investigate gut microflora and their influence on the

levodopa
dopamine
benserazide
dopamine agonists
constipation
  • 0 views
  • 12 Aug, 2021
  • 1 location
Aqua Stand-Up Paddle Balance Effect in Parkinson's Disease (AquaSUP PARK)

Postural instability is associated with falls and a decreased quality of life in Parkinson's disease (PD). Evidence supports physical activity rather than levodopa for postural instability

levodopa
  • 0 views
  • 24 Jan, 2021
  • 1 location
L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults

motor slowing. The central hypothesis of this study is that by enhancing dopamine functioning in the brain and improving cognitive and motor slowing, administration of carbidopa/levodopa (L-DOPA) will

psychotherapy
dopamine
depression
psychosis
antidepressants
  • 0 views
  • 30 Apr, 2021
Dopamine Effect on Inhibitory Control

The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications. A key

  • 0 views
  • 05 Feb, 2021
  • 1 location
1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)

], and behavioral / self-report); and 2) examine the responsivity of dopamine-related circuits and behavior to stimulation with carbidopa/levodopa (L-DOPA).

  • 0 views
  • 31 Mar, 2021
  • 1 location
Social Decision Making in Parkinson's Disease

, and on-DAA visit, and an off-DAA visit. For both the on and off DAA visits, participants will continue taking Carbidopa-Levodopa, but will withdrawal off of other PD related medications. Both visits

dopamine agonists
levodopa
dopamine
neurodegenerative disorders
pramipexole
  • 1 views
  • 25 Jan, 2021
  • 1 location
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist to Treat Impulse Control Disorders in Parkinson's Disease.

frequently leads to a worsening of motor signs (parkinsonism or dyskinesias due to the concomitant increase of levodopa doses) and non-motor signs with the appearance of a DA withdrawal syndrome (DAWS).

dopamine agonists
levodopa
depression
dopamine
dyskinesia
  • 1 views
  • 13 May, 2021
  • 29 locations
A Clinical Trial for the Safety and Effect of MRGuided FUS Subthalamotomy for Medication Refractory Parkinson's Disease

Study design: This is a prospective, open-label, single-center, and sponsor-initiated clinical trial. The clinical trial follows the Clinical Investigation Plan, GCP. Objective: The objective of the clinical trial is to evaluate improving Parkinson's disease motor features by MR-guided focused ultrasound surgery (Patient who has less effectiveness.).

  • 0 views
  • 16 Apr, 2021
  • 1 location
Parkinson's Disease: Enhancing Physical Therapy With Brain Stimulation for Treating Postural Instability.

This trial aims to understand the mechanism and to test whether transcranial direct current stimulation (tDCS) combined with transcranial ultrasound (TUS) (tDCS+TUS) combined with physical therapy (PT) will induce significant therapeutic effects in postural instability in Parkinson's disease (PT) patients. The investigators designed a double-blinded, placebo controlled, randomized study to …

transcranial direct current stimulation
brain stimulation
  • 7 views
  • 24 Jul, 2021
  • 1 location