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Found 56 clinical trials
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. (PIMPARK)

frequently leads to a worsening of motor signs (parkinsonism or dyskinesias due to the concomitant increase of levodopa doses) and non-motor signs with the appearance of a DA withdrawal syndrome (DAWS).

hallucinations
impulse control disorder
amantadine
parkinsonism
anticholinergic agents
  • 2 views
  • 25 Mar, 2022
  • 3 locations
Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease

This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsulesBIFICO on motor symptoms and constipation and sleep in mild to moderate Parkinson's disease and the safety of the study; 2. the mechanism of the improvement effect of intestinal …

parkinson's disease
constipation
motor symptoms
Accepts healthy volunteers
levodopa
  • 0 views
  • 25 Jan, 2022
  • 1 location
Istradefylline for Parkinson Disease With Cognitive Impairment

The purpose of this research study is to determine whether istradefylline improves cognition in individuals with Parkinson disease with cognitive impairment.

carbidopa/levodopa
dementia
istradefylline
levodopa
antiparkinsonian agents
  • 0 views
  • 24 Jul, 2022
  • 1 location
Apomorphine Effects on Pain in Parkinson's Disease

To study the effects of acute apomorphine vs. placebo administration on different Parkinson's disease pain types.

antiparkinsonian agents
apomorphine
  • 0 views
  • 27 May, 2022
  • 1 location
Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies

Dementia with Lewy Bodies (DLB) is an alphasynucleinopathy and the second most common form of dementia in the elderly. DLB shares striking neuropathological and clinical similarities with both Parkinson's disease (PD) and Alzheimer's disease (AD). Nilotinib (Tasigna®, AMN107, Novartis, Switzerland) is approved by the FDA and is well tolerated for …

tremor
hallucinations
amn107
parkinsonism
parkinson's disease
  • 4 views
  • 11 May, 2022
  • 1 location
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

This study is designed to track brain functional changes in individuals with i) chronic back pain + opioid use (CBP+O) and individuals with ii) chronic back pain + opioid misuse disorder (CBP+mOUD) following a brief drug delay and re-exposure manipulation. Re-exposure could be placebo, the participant's own opioid dose, or …

back pain
NSAID
manipulation
low back pain
chronic pain
  • 0 views
  • 23 Jul, 2022
  • 1 location
A Randomized Controlled Trial of Nicotinamide Supplementation in Early Parkinson's Disease (NOPARK)

NOPARK is a double-blinded randomized controlled trial that studies nicotinamide supplementation in early Parkinson's disease. Parkinson's disease (PD) is a major cause of death and disability and has a worldwide socioeconomic impact. It affects ~2% of the population above the age of 65 years and its prevalence increases dramatically as …

datscan
early parkinson's
malnutrition
  • 44 views
  • 25 Jan, 2022
  • 2 locations
The Effect of Spinal Mobilization on Respiratory Parameters in Parkinson's Disease Patients

Parkinson's patients suffer from respiratory distress for different reasons. It is thought that physiotherapy methods that have an indirect effect on the diaphragm can improve respiratory functions. The aim of this study is to investigate the effects of spinal mobilization and diaphragmatic breathing techniques on respiratory function.

  • 0 views
  • 25 Mar, 2022
Predictive Value of Multimodal MRI in Parkinson's Disease

Deep brain stimulation (DBS) is recognized as the most safe and effective neurosurgical method for the treatment of advanced Parkinson's disease. However, the mechanism of relieving motor and non-motor symptoms of Parkinson's disease has not been fully clarified, and the prognosis is significantly different. This study is based on multimodal …

brain stimulation
motor symptoms
  • 0 views
  • 25 Jan, 2022
  • 1 location
Aerobic Exercise and Brain Health in Parkinson's

The purpose of the project is to investigate how moderate to high intensity aerobic exercise affects brain health in patients with Parkinson's disease. Assessments include MRI, blood markers, cognition, functional tests, questionnaires, and cardiorespiratory fitness. The study will be a single blinded randomized controlled trial with a 6-month long intervention.

aerobic exercise
  • 0 views
  • 25 Jan, 2022
  • 1 location