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Found 56 clinical trials
OpiCapone Effect on Motor Fluctuations and pAiN (OCEAN)

The aim of this study is to investigate the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase inhibitor (DDCI), in

antidepressants
levodopa
dopa
  • 0 views
  • 25 Jan, 2022
  • 1 location
Simultaneous DBS of the GPi and the NBM in Patients With Parkinson's Disease and Mild Cognitive Impairment

Phase 1 study evaluating the safety of combined bilateral globus pallidus internus (GPi) and nucleus basalis of Meynert (NBM) stimulation in treating levodopa responsive motor symptoms of

  • 0 views
  • 24 Apr, 2022
  • 1 location
Role of Zonisamide in Advanced Parkinson's Disease (PD) in Egyptian Population: Pilot Study

insufficiently to Levodopa treatment. Most observations of a beneficial effect of ZNS have been in Japanese people, and the antiparkinsonian mechanism of action is unclear. So, ZNS is a promising but

motor symptoms
dyskinesia
levodopa
antiparkinsonian agents
  • 0 views
  • 25 Jan, 2022
  • 2 locations
Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease With Constipation

PD, including levodopa and dopamine agonist, can also cause constipation. In recent years, an increasing number of studies have been conducted to investigate gut microflora and their influence on the

levodopa
carbidopa
antipsychotics
dopamine agonists
dopamine
  • 0 views
  • 25 Jan, 2022
  • 1 location
Dopaminergic Dysfunction in Late-Life Depression (D3)

carbidopa/levodopa (L-DOPA) will improve depressive symptoms.

  • 0 views
  • 12 Mar, 2022
  • 1 location
Aqua Stand-Up Paddle Balance Effect in Parkinson's Disease (AquaSUP PARK) (AquaSUP PARK)

Postural instability is associated with falls and a decreased quality of life in Parkinson's disease (PD). Evidence supports physical activity rather than levodopa for postural instability

levodopa
  • 2 views
  • 25 Jan, 2022
  • 1 location
Microbiota Intervention to Change the Response of Parkinson's Disease (MICRO-PD)

The clinical phenotype of Parkinson's disease (PD) is quite variable, as is the response to and side effects from medications. While many patients respond to carbidopa/levodopa early on, motor

dyskinesia
levodopa
carbidopa
carbidopa/levodopa
  • 35 views
  • 15 Mar, 2022
  • 1 location
Dopamine Effect on Inhibitory Control (DEI)

The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications. A key

dopamine agonists
dyskinesia
Accepts healthy volunteers
levodopa
dopamine
  • 0 views
  • 02 Jun, 2022
  • 1 location
Social Decision Making in Parkinson's Disease

, and on-DAA visit, and an off-DAA visit. For both the on and off DAA visits, participants will continue taking Carbidopa-Levodopa, but will withdrawal off of other PD related medications. Both visits

neurodegenerative disorders
dopamine agonists
carbidopa/levodopa
levodopa
pramipexole
  • 1 views
  • 18 May, 2022
  • 1 location
Speed Manipulated Adaptive Rehabilitation Therapy Bike for Parkinson's Disease (SMART)

patients' quality of life, independence, and functional performance. There is currently no cure for PD, but symptoms can be treated with levodopa or deep brain stimulation surgery. Exercise-based

tremor
levodopa
brain stimulation
  • 0 views
  • 10 May, 2022
  • 1 location