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Found 61 clinical trials
Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing

In this new research study, 80 adults aged > 60 years with a significant depressive disorder and slowed processing and/or gait speed will be randomized to receive levodopa (L-DOPA; which the

depressive disorder
depression
depressed mood
  • 0 views
  • 03 Aug, 2021
  • 1 location
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy

This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on …

movement disorder
levodopa
parkinson's disease
dyskinesia
  • 0 views
  • 13 Sep, 2021
  • 2 locations
Assessing the Pharmacokinetics Safety Tolerability and Efficacy of Continuous Oral Levodopa Via the DopaFuse Delivery System in Parkinson's Disease Patients

The purpose of this study is to evaluate whether the DopaFuse System can reduce the fluctuation of plasma levodopa levels compared to participants' standard intermittent doses of oral LD/CD

levodopa
motor symptoms
mini-mental state examination
carbidopa
mental state examination
  • 0 views
  • 13 Sep, 2021
  • 4 locations
INfusion VErsus STimulation in Parkinson's Disease

Both Continuous intrajejunal Levodopa Infusion (CLI) and Deep Brain Stimulation (DBS) are accepted therapies for the treatment of advanced Parkinson's disease (PD). To date, no comparative

bradykinesia
brain stimulation
dyskinesia
carbidopa
levodopa
  • 35 views
  • 22 Jan, 2021
  • 1 location
Effects of Lingzhi on Disease Progression in Patients With Untreated Early Parkinson's Disease

Lingzhi(Ganoderma) is widely used in traditional Chinese medicine. Previous studies indicated that Lingzhi was safe, well tolorated, and improved symptoms as an add-on therapy to levodopa in

antiparkinsonian agents
levodopa
early parkinson's
  • 1 views
  • 05 Sep, 2021
  • 1 location
Effect of GOCOVRI (Amantadine Extended Release Capsules) on Gait in Parkinson's Disease

) and levodopa induced dyskinesia (LID) during daily activities using body-worn sensors.

  • 0 views
  • 29 Apr, 2021
  • 1 location
OpiCapone Effect on Motor Fluctuations and pAiN

The aim of this study is to investigate the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase inhibitor (DDCI), in

dopa
levodopa
antidepressants
  • 0 views
  • 10 Aug, 2021
  • 1 location
OpicApone Sleep dISorder

The aim of this study is to To investigate in an exploratory manner the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase

dopa
levodopa
  • 0 views
  • 12 Aug, 2021
  • 1 location
Role of Zonisamide in Advanced Parkinson's Disease (PD) in Egyptian Population: Pilot Study

insufficiently to Levodopa treatment. Most observations of a beneficial effect of ZNS have been in Japanese people, and the antiparkinsonian mechanism of action is unclear. So, ZNS is a promising but

antiparkinsonian agents
levodopa
motor symptoms
dyskinesia
  • 0 views
  • 06 Aug, 2021
  • 2 locations
Dopaminergic Dysfunction in Late-Life Depression

carbidopa/levodopa (L-DOPA) will improve depressive symptoms.

  • 0 views
  • 24 Feb, 2021
  • 1 location