Found 61 clinical trials
Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing
In this new research study, 80 adults aged > 60 years with a significant depressive disorder and slowed processing and/or gait speed will be randomized to receive levodopa (L-DOPA; which the
- 0 views
- 03 Aug, 2021
- 1 location
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on …
- 0 views
- 13 Sep, 2021
- 2 locations
Assessing the Pharmacokinetics Safety Tolerability and Efficacy of Continuous Oral Levodopa Via the DopaFuse Delivery System in Parkinson's Disease Patients
The purpose of this study is to evaluate whether the DopaFuse System can reduce the fluctuation of plasma levodopa levels compared to participants' standard intermittent doses of oral LD/CD
- 0 views
- 13 Sep, 2021
- 4 locations
INfusion VErsus STimulation in Parkinson's Disease
Both Continuous intrajejunal Levodopa Infusion (CLI) and Deep Brain Stimulation (DBS) are accepted therapies for the treatment of advanced Parkinson's disease (PD). To date, no comparative
- 35 views
- 22 Jan, 2021
- 1 location
Effects of Lingzhi on Disease Progression in Patients With Untreated Early Parkinson's Disease
Lingzhi(Ganoderma) is widely used in traditional Chinese medicine. Previous studies indicated that Lingzhi was safe, well tolorated, and improved symptoms as an add-on therapy to levodopa in
- 1 views
- 05 Sep, 2021
- 1 location
Effect of GOCOVRI (Amantadine Extended Release Capsules) on Gait in Parkinson's Disease
) and levodopa induced dyskinesia (LID) during daily activities using body-worn sensors.
- 0 views
- 29 Apr, 2021
- 1 location
OpiCapone Effect on Motor Fluctuations and pAiN
The aim of this study is to investigate the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase inhibitor (DDCI), in
- 0 views
- 10 Aug, 2021
- 1 location
OpicApone Sleep dISorder
The aim of this study is to To investigate in an exploratory manner the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase
- 0 views
- 12 Aug, 2021
- 1 location
Role of Zonisamide in Advanced Parkinson's Disease (PD) in Egyptian Population: Pilot Study
insufficiently to Levodopa treatment. Most observations of a beneficial effect of ZNS have been in Japanese people, and the antiparkinsonian mechanism of action is unclear. So, ZNS is a promising but
- 0 views
- 06 Aug, 2021
- 2 locations
Dopaminergic Dysfunction in Late-Life Depression
carbidopa/levodopa (L-DOPA) will improve depressive symptoms.
- 0 views
- 24 Feb, 2021
- 1 location