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Found 56 clinical trials
Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease

Levodopa is a precursor of dopamine and is the treatment of choice to treat the motor symptoms of Parkinson's disease (PD); however, the effect of levodopa on cardiovascular autonomic function

systolic blood pressure
parkinson's disease
orthostatic hypotension
levodopa
dopamine
  • 0 views
  • 12 Aug, 2022
  • 1 location
Efficacy, Safety and Pharmacokinetic Study of CPL500036 in Patients With Levodopa Induced Dyskinesia

The aim of the study is to determine potential anti-dyskinetic properties of CPL500036 (PDE10A inhibitor) in Parkinson disease patients suffering from levodopa Induced dyskinesia. The study is

levodopa
dyskinesia
  • 0 views
  • 27 May, 2022
  • 4 locations
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy

This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on …

parkinson's disease
movement disorder
levodopa
dyskinesia
  • 47 views
  • 04 Jun, 2022
  • 41 locations
A Pharmacodynamics and Safety Study of DSP-9632P in Patients With Levodopa-Induced Dyskinesia in Parkinson's Disease

This study is an open-label of single transdermal dose of DSP-9632P to evaluate the dopamine release derived from levodopa in brain, and a randomized, double-blind, placebo-controlled, 2-way

levodopa
dopamine
dyskinesia
  • 0 views
  • 11 Jul, 2022
  • 1 location
Deep Brain Stimulation of the Cuneiform Nucleus for Levodopa-resistant Freezing of Gait in Parkinson's Disease (DBS + FOG)

The purpose of this research study is to determine if DBS is a safe and effective therapy for severe freezing of gait in patients with Parkinson's Disease. Freezing of gait (FOG) is a particularly debilitating motor deficit seen in a subset of patients with Parkinson's Disease (PD).

movement disorder
dementia
tremor
progressive supranuclear palsy
levodopa
  • 0 views
  • 25 Jan, 2022
  • 1 location
Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy

This open-label study is designed to assess the long-term safety and tolerability of dipraglurant in PD patients for up to 52 weeks (at doses of 150-300 mg per day) for patients that have completed an Addex sponsored double-blind clinical trial of dipraglurant.

parkinson's disease
levodopa
  • 8 views
  • 13 May, 2022
  • 7 locations
A Study of the Efficacy and Safety of Carbidopa-Levodopa Extended-Release Tablets in Patients With Parkinson's Disease

It is a phase II randomized, parallel, double-blind, placebo-controlled, multi-center clinical trial of the efficacy and safety of WD-1603 Carbidopa-Levodopa Extended-Release Tablets in patients

carbidopa/levodopa
levodopa
carbidopa
early parkinson's
  • 0 views
  • 25 Jan, 2022
  • 1 location
A Study to Evaluate the Efficacy and Safety of Safinamide Mesilate as Add-on Therapy to Levodopa in Parkinson's Disease Participants With Motor Fluctuation in South Korea

participants with Parkinson's Disease who are receiving levodopa.

movement disorder
safinamide
dementia
levodopa
dopamine
  • 0 views
  • 09 May, 2022
Novel Non-opioid Post-surgical Pain Treatment in Females

This study aims to determine if treatment with Carbidopa/Levodopa and Naproxen in females (biological sex) with acute pain after a bunionectomy or toe fusion (24hrs, 48hrs and 5 days) will

acute pain
opioid
naproxen
bunionectomy
  • 0 views
  • 27 Nov, 2021
  • 1 location
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease

) and levodopa induced dyskinesia (LID) during daily activities using body-worn sensors.

levodopa
amantadine
dyskinesia
  • 0 views
  • 25 Jan, 2022
  • 1 location