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Found 17 clinical trials
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease (TRIP)

The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's disease

cognitive impairment
dementia
Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 1 location
Post-stroke Epilepsy: Primary Prophylaxis Study

-epileptogenesis in the phase of epileptogenesis. Based on our clinical experience, and laboratory researches, we have noted two non-conventional AEDs, levetiracetam (LEV) and perampanel (PER) with

  • 0 views
  • 08 May, 2021
  • 1 location
Effect of Perampanel on Peritumoral Hyperexcitability in HGG

The purpose of this research study is to learn more about seizures in people with primary brain tumors. It will evaluate whether an antiseizure medication decreases hyperexcitability activity around tumors and prevents seizures. The procedure and study drug involved in this study are: Electrocorticography Perampanel (Fycompa)

cancer
astrocytoma, anaplastic
seizure
total bilirubin
cardiotoxic agents
  • 64 views
  • 23 Aug, 2021
Population Pharmacokinetics of Antiepileptic in Pediatrics

The purpose of this study is to develop population pharmacokinetic models for antiepileptic drugs in a pediatric population. The interest of these models is multiple: describe the pharmacokinetics of these molecules in children and explain the inter-individual variability of concentrations through covariates such as weight, age, co-treatments, genetic polymorphisms and …

brivaracetam
oxcarbazepine
cannabidiol
levetiracetam
phenytoin
  • 21 views
  • 25 Jan, 2021
  • 1 location
A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury

This study aims is to describe the pharmacokinetic properties of levetiracetam through measurement of serum concentrations in critically ill, severe traumatic brain injury patients.

  • 0 views
  • 15 Apr, 2021
  • 1 location
Blood Brain Barrier Differences in Patients With Brain Tumors Undergoing Surgery

This pilot research trial studies blood brain barrier differences in patients with brain tumors undergoing surgery. Studying samples of tissue and blood from patients with brain tumors in the laboratory may help doctors to understand how well drugs get into different parts of a brain tumor. This may help them …

cancer
cns malignancy
primary brain tumors
metastasis
renal failure
  • 0 views
  • 31 Jan, 2022
  • 1 location
Brivaracetam: a Prospective and Multicentre Post-marketing Observational Study

Brivaracetam (BRV) is a new antiepileptic drug approved in March 2016 by Health Canada for the adjunctive treatment of focal epilepsy in adults. While randomized controlled trials represent the gold standard in measuring intervention efficacy, the generalizability of these findings to usual clinical practice remains uncertain. The primary objective of …

brivaracetam
generalized epilepsy
adjunctive treatment
convulsive seizure
partial epilepsy
  • 48 views
  • 30 Sep, 2021
  • 1 location