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Found 128 clinical trials
Phase I Study of GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)

symptoms and their ability to perform their normal activities Tumor biopsy Imaging scan of the chest, abdomen, and pelvis Participants will have leukapheresis. They may have an IV

EGFR
cancer
measurable disease
immunohistochemistry
  • 0 views
  • 23 Sep, 2022
  • 1 location
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers

each vaccine. Vaccinees may choose to have: Leukapheresis. Blood will be removed by needle in a vein in one arm. A machine will remove white blood cells. The rest of the blood will be

Accepts healthy volunteers
blood test
cervical cap
vasectomy
oophorectomy
  • 96 views
  • 21 Jul, 2022
  • 1 location
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

, urinate, then lie in the scanner. A mask will hold the head still. Leukapheresis. An optional procedure at baseline. White blood cells are removed from you using a serum cell separator machine

antibody test
antiretroviral agents
cancer
HIV Vaccine
antiretroviral therapy
  • 62 views
  • 25 Jul, 2022
  • 1 location
A Prospective Randomized and Phase II Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor-Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

urine tests Before treatment, participants will have: A piece of tumor taken from a biopsy or during surgery in order to grow TIL cells Leukapheresis: Blood flows through a needle

metastatic melanoma
gilbert's syndrome
cancer
systemic therapy
preparative regimen
  • 21 views
  • 19 Sep, 2022
  • 1 location
A Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

procedure called leukapheresis. Leukapheresis is the removal of the blood by a machine to collect specific white blood cells. The remaining blood is returned to the body. This procedure is needed to

  • 0 views
  • 14 Sep, 2022
  • 1 location
CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

biopsy, and/or spinal tap Some participants will have lung tests. Participants will repeat these tests throughout the study and follow-up. Participants will have leukapheresis

gm-csf
cancer
immunohistochemistry
tyrosine
kinase inhibitor
  • 42 views
  • 09 Aug, 2022
  • 1 location
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

. Participants will have leukapheresis: Blood is removed by a needle in one arm. A machine removes white blood cells. The rest of the blood is returned by a needle in the other arm. Care at home over

tumor cells
cancer
white blood cells
chemotherapy regimen
irinotecan
  • 69 views
  • 26 Jul, 2022
  • 1 location
Autologous CD30.CAR-T in Combination With Nivolumab in cHL Patients After Failure of Frontline Therapy (ACTION)

This is a Phase 1b, multicenter, open-label, single arm study to evaluate the safety and efficacy of the combination therapy, CD30.CAR-T and the programmed cell death protein-1 (PD-1) checkpoint inhibitor, nivolumab, in patients aged 12 years of age and above with relapsed or refractory classical Hodgkin lymphoma (cHL) following failure …

  • 0 views
  • 10 Jul, 2022
  • 2 locations
BATs in Patients With Breast Cancer and Leptomeningeal Metastases

This study uses bi-specific antibody (HER2Bi) armed activated T-cells (HER2 BATs) to target breast cancer cells that have metastasized to the membranes surrounding the brain and spinal cord. This is known as leptomeningeal metastases. Two doses will be evaluated in order to determine a safe dose. Study treatment includes a …

neutrophil count
cancer
breast cancer
estrogen
HER2
  • 3 views
  • 03 Feb, 2022
  • 1 location
Pilot Study for Patients With Chemotherapy Resistant or Refractory CD19 Leukemia and Lymphoma

This is a study for people who have been previously treated for Leukemia/Lymphoma. In particular, it is a study for people who have a type of Leukemia/Lymphoma that involves B cells (a type of white cell), which contain the cancer. This is a new approach for treatment of Leukemia/Lymphoma that …

tumor cells
leukemia
lymphoma
cancer
  • 71 views
  • 07 Nov, 2020
  • 1 location