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Found 127 clinical trials
Dose-Evaluation Study of the Efficacy and Safety of TLA Gut™ Leukapheresis Treatment in Patients With Ulcerative Colitis

An open-label, randomised, multi-centre, dose evaluation study of the efficacy and safety of TLA Gut™ leukapheresis treatment in patients with UC. The aim of this trial is to evaluate the

certolizumab pegol
infliximab
tumor necrosis factor
corticosteroids
azathioprine
  • 0 views
  • 07 Oct, 2022
  • 1 location
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

recipients. DCreg will be prepared from monocytes obtained by leukapheresis from prospective (non-mobilized) living kidney donors and infused into the respective recipients 7 days before renal

hepatitis b
live donor renal transplant
Accepts healthy volunteers
ifng
donor renal transplantation
  • 26 views
  • 04 Feb, 2022
  • 1 location
Safety and Efficacy of Anti-BCMA/GPRC5D CAR-T Cell Therapy in Treating Relapsed and Refractory Multiple Myeloma(rr/MM)

This is an open label, single-arm, Phase 2 study to evaluate the efficacy and safety of Anti-BCMA/GPRC5D CAR-T in subjects with relapsed and refractory multiple myeloma. A leukapheresis

bortezomib
refractory multiple myeloma
chemotherapy regimen
fludarabine
leukemia
  • 0 views
  • 04 Oct, 2022
  • 1 location
Pilot Study of Haploidentical Donor Adenovirus Specific T-lymphocytes to Treat Refractory Adenovirus Infections (ADV-VSTS)

This open-label, single-arm, phase I/II clinical trial will assess the safety and efficacy of related donor adenovirus-specific T lymphocytes isolated from whole blood or leukapheresis products

  • 0 views
  • 07 Oct, 2022
  • 1 location
Study of CRX100 in Patients With Advanced Solid Tumors

tumors. Patients will be screened and evaluated to determine whether or not they meet stated inclusion criteria. Enrolled subjects will undergo leukapheresis to enable the ex vivo generation of

neutrophil count
human chorionic gonadotropin
HER2
cellular therapy
carcinoma
  • 2 views
  • 04 Oct, 2022
  • 3 locations
A Phase II Study Using Autologous Young Tumor-Infiltrating Lymphocytes Derived From Patients With Non-Small Cell Lung Cancer Following Non-Myeloablative Lymphocyte Depleting Preparative Regimen

Surgery: If the patients meet all of the requirements for the study they will undergo surgery to remove a tumor that can be used to grow the TIL product. Leukapheresis: Patients may

lung cancer
x-rays
alt/ast
chemotherapy regimen
wbc count
  • 34 views
  • 17 Sep, 2022
  • 1 location
RENEW: Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients.

In prior trials of CMV RNA-pulsed dendritic cell vaccines, there has been a narrow window between surgery and initiation of chemoradiation to enroll patients and perform leukapheresis (to obtain

sargramostim
temozolomide
platelet count
neutrophil count
beam radiation
  • 0 views
  • 15 May, 2022
  • 1 location
A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab

grow the TIL product. Leukapheresis: Patients may undergo leukapheresis to obtain additional white blood cells. {Leukapheresis is a common procedure, which removes only the white blood cells

cyclophosphamide
sorafenib
ovarian cancer
x-rays
brain metastases
  • 39 views
  • 23 Sep, 2022
  • 1 location
HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+Breast Cancer

collected from a procedure called leukapheresis. Dendritic cells are immune cells that can tell the immune system to fight infection. In laboratory testing and from previous studies in participants, these

pertuzumab
her-2
female breast cancer
invasive carcinoma
breast cancer
  • 95 views
  • 07 Oct, 2022
  • 1 location
Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells

Cytomegalovirus (CMV) infections with virus-specific, antigen-selected T-cells. CMV-specific T-cells will be isolated from donor leukapheresis products using the CliniMACS® Prodigy. Prior studies on transfer of

stem cell transplantation
viremia
foscarnet
pneumonia
dhpg
  • 41 views
  • 08 Feb, 2022
  • 1 location