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Found 122 clinical trials
Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

This study will combine both T cells and antibodies in order to create a more effective treatment. The treatment tested in this study uses modified T-cells called Autologous T Lymphocyte Chimeric Antigen Receptor (ATLCAR) cells targeted against the kappa light chain antibody on cancer cells. For this study, the anti-kappa …

cancer
fludarabine
refractory follicular lymphoma
cyclophosphamide
lymphoma cells
  • 15 views
  • 09 Dec, 2021
  • 1 location
Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

bone marrow, lymph node, genitals, or in or around the anus. Participants may have leukapheresis. Blood is taken from a needle placed in one arm. A machine separates out the white blood cells

Accepts healthy volunteers
  • 6 views
  • 04 Oct, 2022
  • 1 location
PET Imaging and Lymph Node Assessment of IRIS in Persons With AIDS

Background Sometimes people with HIV, the virus that causes AIDS, can have new or worsening symptoms soon after starting HIV medications. Often these symptoms are caused by immune reconstitution inflammatory syndrome (IRIS). Researchers want to study why and how people develop IRIS and how best to prevent and treat it. …

  • 0 views
  • 28 Oct, 2022
  • 1 location
A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.

Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers. The preliminary objective of this study is aimed at selecting PD-1+ and CTLA4+ T cells and other cellular fractions from peripheral blood of cancer patients and healthy …

solid tumor
cancer
neutrophil count
tumor cells
metastasis
  • 41 views
  • 16 May, 2022
  • 1 location
Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral-Naive HIV-Infected Patients

There is evidence that early and aggressive treatment with antiretroviral drugs can prevent the loss of immune cell function that accompanies HIV infection. This study will use leukapheresis

HIV Infection
leukapheresis
haart
antiretroviral therapy
antiretroviral agents
  • 55 views
  • 25 Oct, 2022
  • 1 location
COVID-19-associated Lymphopenia Pathogenesis Study in Blood

through that instead. Participants medical records related to COVID-19 will be reviewed. Participants who have recovered from COVID-19 will be asked to undergo leukapheresis to collect

  • 15 views
  • 14 Oct, 2022
  • 3 locations
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations

> Participants will have a physical examination and the following tests: Blood tests Includes HLA-typing, a genetic test of immune system markers; Leukapheresis Collection of large numbers of white

genetic test
ospa vaccine
antibiotics
chronic lyme disease
arthritis
  • 2438 views
  • 27 Oct, 2022
  • 1 location
Natural History and Genetics of Food Allergy and Related Conditions

are placed on the back or arm. The skin is scratched under each drop. Leukapheresis: blood is taken from a needle in one arm, passed through a machine, and returned through a needle in the

Accepts healthy volunteers
eosinophilic esophagitis
allergen
scratch
platelet count
  • 85 views
  • 07 Oct, 2022
  • 1 location
Tumor, Normal Tissue and Specimens From Patients Undergoing Evaluation or Surgical Resection of Solid Tumors

> Before their procedure, participants will have a small blood sample taken. Some participants will undergo leukapheresis. In this procedure, blood is removed

solid tumor
cancer
white blood cell count
solid tumour
  • 18 views
  • 29 Oct, 2022
  • 1 location
Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples From Patients With Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family Members

who are 18 years of age or older may donate a large number of white blood cells through a procedure called leukapheresis. This procedure is not part of general medical care and would be done for

solid tumor
blood disorder
malignant solid neoplasm
leukapheresis
bone marrow procedure
  • 43 views
  • 21 Oct, 2022
  • 1 location