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Found 107 clinical trials
Safety of Combining Irinotecan With 5-FU Leucovorin/Folinic Acid Oxaliplatin and Docetaxel Chemotherapies

The purpose of the proposed study is to establish the safety of combining irinotecan chemotherapy with 5-FU, leucovorin/folinic acid, oxaliplatin, and docetaxel (abbreviated as the I-FLOAT study

oxaliplatin
chemotherapy regimen
neutrophil count
primary tumor
pancreatic adenocarcinoma
  • 0 views
  • 20 Jun, 2021
  • 1 location
Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder

leucovorin, is approved by the U.S. Food and Drug Administration (FDA) to decrease side effects during cancer chemotherapy. Folinic acid may be helpful in treating language problems in children with autism

pervasive developmental disorder
leucovorin
speech therapy
investigational drug
autism
  • 222 views
  • 22 Mar, 2022
  • 3 locations
Perioperative Leucovorin, Oxaliplatin, Docetaxel and S-1 (LOTS) For Locally Advanced Gastric or Gastroesophageal Junction Cancer (LOTS)

The aim of the trial is to investigate the clinical efficacy and toxicity of perioperative chemotherapy with leucovorin, oxaliplatin, docetaxel and S-1 (LOTS) in patients with locally advanced

Accepts healthy volunteers
  • 0 views
  • 09 Jun, 2022
  • 2 locations
A Study of Bevacizumab Infusional Fluorouracil Leucovorin Oxaliplatin and Irinotecan (A-FOLFOXIRI) Compared With Bevacizumab Infusional Fluorouracil Leucovorin and Irinotecan/Oxaliplatin (A-FOLFIRI/FOLFOX) as First-line Treatment for Metastatic Right-sided Colon Cancer

RATIONALE: Recently, the importance of prognosis according to the location of the primary tumor in colorectal cancer has been raised. In the CALGB / SWOG 80405 study published in 2016, the addition of bevacizumab or cetuximab to the first line FOLFIRI / FOLFOX in KRAS (codon 12, 13) wild type …

  • 0 views
  • 25 Jan, 2021
  • 1 location
  • 0 views
  • 05 Jul, 2021
  • 1 location
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

This phase I/II trial studies the side effects and best dose of liposomal irinotecan and rucaparib when given together with fluorouracil and leucovorin calcium and to see how well they work in

metastatic adenocarcinoma
leucovorin
vasectomy
oophorectomy
tumor cells
  • 8 views
  • 16 Jun, 2022
  • 3 locations
Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with

metastatic adenocarcinoma
combinations
leucovorin
neutrophil count
paclitaxel
  • 0 views
  • 19 Jun, 2022
  • 43 locations
Liposomal Irinotecan, Fluorouracil and Leucovorin in Treating Patients With Refractory Advanced High Grade Neuroendocrine Cancer of Gastrointestinal, Unknown, or Pancreatic Origin

This phase II trial studies how well liposomal irinotecan, leucovorin, and fluorouracil work in treating patients with high grade neuroendocrine cancer of gastrointestinal, unknown, or

  • 48 views
  • 30 Jun, 2022
  • 2 locations
Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer

This pilot clinical trial studies genetic analysis-guided irontecan hydrochloride dosing of modified fluorouracil, irinotecan hydrochloride, leucovorin calcium, oxaliplatin (mFOLFIRINOX) in

oxaliplatin
leucovorin
neutrophil count
cancer
conventional surgery
  • 67 views
  • 17 Jun, 2022
  • 3 locations
FOLFOX6 Versus mFOLFIRINOX as First Line Chemotherapy in Metastatic Gastric Cancer or Esophagogastric Junction Adenocarcinoma (Type II-III)

. One half of the patients gets 5-Fluorouracil (5-FU), Leucovorin, Oxaliplatin (FOLFOX6), the others 5-Fluorouracil (5-FU), Leucovorin, Oxaliplatin and Irinotecan (mFOLFIRINOX). Main objective of the

  • 0 views
  • 21 Apr, 2021
  • 1 location