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Found 86 clinical trials
GCC 1366: Anti-Proliferative Response to NeoAdjuvant AIs in Overweight and Obese Patients

(Arimidex®) and Letrozole (Femara®) are AIs that are approved by the Food and Drug Administration (FDA). They have been used since 2005 to treat women with early stage breast cancer. When given

arimidex
primary tumor
letrozole
aromatase inhibitor
mammogram
  • 19 views
  • 13 May, 2022
  • 1 location
Pembrolizumab, Endocrine Therapy, and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast Cancer

, and may interfere with the ability of tumor cells to grow and spread. Estrogen can cause the growth of breast cancer cells. Fulvestrant blocks the use of estrogen by the tumor cells. Letrozole lowers

hysterectomy
biomarker analysis
letrozole
palbociclib
estrogen
  • 99 views
  • 13 Apr, 2022
  • 7 locations
Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype (HARMONIA)

therapy (letrozole or fulvestrant) is superior to palbociclib with endocrine therapy (letrozole or fulvestrant) in prolonging progression-free survival in patients with advanced HR+/HER2- and HER2-E

  • 0 views
  • 21 Apr, 2022
  • 4 locations
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors (CDK4)

phase 2 dose (RP2D). In Part 1B and Part 1C, PF-07220060 will be administered in combination with 1 of 2 endocrine therapies (letrozole and fulvestrant, respectively). In Part 1D, food

epidermal growth factor
immunomodulators
cancer
letrozole
adenocarcinoma
  • 1 views
  • 23 Mar, 2022
  • 10 locations
Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis (APPOSE)

Randomized double blinded placebo-controlled trial to evaluate the impact of ovarian hyperstimulation on endometriosis-related symptoms and to evaluate the impact of letrozole use during ovarian

endometriosis
Accepts healthy volunteers
endometrioma
letrozole
surgical diagnosis
  • 207 views
  • 24 Feb, 2022
  • 1 location
Transcutaneous Electroacupuncture for Gastrointestinal Motility Disorders

Randomized double blinded placebo-controlled trial to evaluate the impact of ovarian hyperstimulation on endometriosis-related symptoms and to evaluate the impact of letrozole use during ovarian

peptic ulcer
bloating
upper endoscopy
nausea
constipation
  • 59 views
  • 17 Oct, 2021
  • 1 location
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial

The overall objective of this randomized trial is to investigate the effects of treatment of AAS- induced male hypogonadism with combined therapy of letrozole and hCG compared with placebo on

testosterone
hormone levels
male hypogonadism
testosterone level
screening procedure
  • 0 views
  • 23 Mar, 2022
  • 1 location
Combined Immunotherapies in Metastatic ER+ Breast Cancer

metastatic HR+ Breast cancer(BC) (letrozole+palbociclib) are randomly assigned to also receive Stereotactic Body Radiation Therapy(SBRT) to each metastatic lesion.

growth factor
epidermal growth factor
estradiol
EGFR
tamoxifen
  • 0 views
  • 11 Jul, 2021
  • 5 locations
Study of PF-07248144 in Advanced or Metastatic Solid Tumors (KAT6)

a single agent and in combination with either fulvestrant or letrozole + palbociclib.

  • 6 views
  • 23 Mar, 2022
  • 14 locations
Safety Tolerability Pharmacokinetics and Antitumor Activity of FCN-437c

combination with letrozole in women with ER +/ HER2 - advanced breast cancer.

hormone therapy
cancer
tamoxifen
letrozole
measurable disease
  • 0 views
  • 25 Jan, 2021
  • 1 location