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Found 86 clinical trials
A 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancer

This is a neoadjuvant study to determine the feasibility and tolerability of 2 weeks of a very low carbohydrate ketogenic diet in combination with letrozole for patients with early stage

invasive breast cancer
core needle biopsy
primary tumor
estradiol
oophorectomy
  • 5 views
  • 12 Feb, 2022
  • 1 location
A Phase II, Two-Arm Study of Everolimus and Letrozole, +/- Ribociclib (Lee011) in Patients With Advanced or Recurrent Endometrial Carcinoma

This phase II trial studies how well everolimus and letrozole with or without ribociclib work in treating participants with endometrial cancer that has spread to other areas of the body or has

lee011
cancer
metastatic disease
non-target
liver metastasis
  • 80 views
  • 27 Jan, 2022
  • 2 locations
Pyrotinib Maleate CDK4/6 Inhibitor and Letrozole in Combination for Stage II-III TPBC: a Phase II Trial

of breast cancer by pyrotinib maleate combined with CDK4/6 inhibitor. Based on above, it is hypothesized that pyrotinib maleate, CDK4/6 inhibitor SHR6390 and aromatase inhibitor letrozole in

immunohistochemistry
progesterone receptor
hormone therapy
endocrine therapy
erbb2
  • 0 views
  • 27 Jul, 2021
  • 1 location
Phase IB & II Study of Ribociclib With Trastuzumab Plus Letrozole in Postmenopausal HR+, HER2+ Advanced Breast Cancer Patients

better PFS than ET alone (TAnDEM trial and trial comparing lapatinib plus letrozole versus letrozole alone) [2],[3] confirming existence of cross talk between ER and HER2 pathways in clinical setting

cancer
lapatinib
her2/neu-positive breast cancer
liver metastasis
chromogenic in situ hybridization
  • 0 views
  • 30 May, 2022
  • 1 location
Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or

carboplatin
paclitaxel
tumor cells
peritoneal cancer
primary peritoneal carcinoma
  • 207 views
  • 16 Jun, 2022
  • 469 locations
Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-II Breast Cancer

efficacy of aromatase inhibitor therapy such as letrozole. Letrozole may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

  • 0 views
  • 14 May, 2022
  • 1 location
Myo-Inositol for Infertility in PCOS

This will be a prospective, double-blind randomized clinical trial of letrozole and placebo versus letrozole and inositols for up to 5 treatment cycles of ovulation induction or until pregnancy

  • 57 views
  • 30 May, 2022
  • 1 location
ABemaciclib, ET ± paclItaxel in aGgressive HR+/HER2- MBC trIaL (ABIGAIL)

This is a multicenter, randomized, 2 arm, open label, phase II study. It is designed to compare the efficacy and safety of abemaciclib combined with ET (letrozole or fulvestrant) versus a short

  • 0 views
  • 29 Jun, 2022
  • 23 locations
Impact of Omega 3 Fatty Acid Supplementation on Aromatase in Obese Subjects

Assess the impact of dietary omega 3 free fatty acids and/or letrozole on obese, postmenopausal breast cancer patients.

estrogen receptor
estrogen
aromatase inhibitor
cancer treatment
letrozole
  • 213 views
  • 23 Feb, 2022
  • 1 location
Neoadjuvant ArOMatase Inhibitor Therapy for ER+ Breast Cancer (NAOMI)

This is a single-arm, open-label study testing the effects of neoadjuvant therapy with the aromatase inhibitor letrozole in post-menopausal women with Stage I-III ER+, HER2- breast cancer

estrogen receptor
aromatase inhibitor
hormone therapy
endocrine therapy
erbb2
  • 0 views
  • 16 Nov, 2021
  • 2 locations