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Found 39 clinical trials
Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas

This pilot phase I trial studies how well itacitinib works in treating patients with sarcomas that do not respond to treatment (refractory) and have spread to other parts of the body (advanced/metastatic). Itacitinib may cause changes in the immune system and the body's immune response to cancer, which may stop …

  • 32 views
  • 07 Mar, 2022
  • 1 location
Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas (REGOSTA)

This is a randomized, double-blinded, 2 arms study concerning patients with bone sarcoma after the first line therapy. In the first arm, patients will be treated with regorafenib for a maximum of 12 months as maintenance therapy after first line therapy, whereas in the second arm, patients will be treated …

localized disease
ifosfamide
neutrophil count
glomerular filtration rate
lipase
  • 1 views
  • 23 May, 2022
  • 4 locations
Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

This phase II trial studies the side effects of talimogene laherparepvec and radiation therapy and to see how well they work in treating patients with newly diagnosed soft tissue sarcoma that can be removed by surgery. Biological therapies, such as talimogene laherparepvec, use substances made from living organisms that may …

liposarcoma
undifferentiated pleomorphic sarcoma
neutrophil count
myxoid liposarcoma
leiomyosarcoma
  • 28 views
  • 17 Jun, 2022
  • 9 locations
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

metastatic malignant peripheral nerve sheath tumors (MPNST), endometrial stromal sarcomas (ESS) and leiomyosarcoma (LMS). Participants will continue on study until disease progression or unacceptable side

kidney function tests
growth factor
neutrophil count
measurable disease
leiomyosarcoma
  • 0 views
  • 18 Apr, 2022
  • 1 location
Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

This study is being done to find the safest dose of DCC-3014 that can be given with avelumab to participants with advanced or metastatic sarcomas that will not cause serious side effects.

liposarcoma
systemic therapy
liver metastases
undifferentiated pleomorphic sarcoma
neutrophil count
  • 22 views
  • 16 Mar, 2022
  • 1 location
Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL) (MABEL)

(HD) or non-Hodgkin Lymphoma (NHL)), T/NK-lymphoproliferative disease, or CAEBV, or solid tumors such as nasopharyngeal carcinoma (NPC), smooth muscle tumors, and leiomyosarcomas show signs of a virus

hodgkin's disease
solid tumour
lymphoproliferative disorder
pulse oximetry
chemotherapy regimen
  • 11 views
  • 24 Mar, 2022
  • 2 locations
Combination Immunotherapy in Rare Cancers Under InvesTigation (MOST-CIRCUIT)

leiomyosarcoma and vaginal/vulva squamous cell carcinoma Mismatch repair protein deficient (MSI-H) cancers (excluding colorectal carcinoma). The role of immunotherapy is being defined in

  • 4 views
  • 07 Apr, 2022
  • 9 locations
Clinical and Biological Activity of an Anti-PD-L1 (Atezolizumab) in Operable Localised Soft Tissue Sarcomas Patients to be Treated With Radiotherapy (RT-Immune)

practice. Randomisation will be stratified according to histological subtypes as follows: Group 1: Liposarcoma (LPS), Undifferentiated Pleomorphic Sarcoma (UPS), Leiomyosarcoma (LMS

liposarcoma
angiosarcoma
undifferentiated pleomorphic sarcoma
kidney function tests
neutrophil count
  • 30 views
  • 24 Apr, 2022
  • 5 locations
Pemetrexed Cisplatin With Soft Tissue Sarcoma

received up to two-lines of prior palliative anticancer treatments with histological subtype-specific cohorts (leiomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, and others) in

  • 0 views
  • 02 May, 2021
  • 1 location
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

This phase I trial studies the side effects of BO-112 when given together with nivolumab before surgery in treating patients with soft tissue sarcoma that can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere …

liposarcoma
undifferentiated pleomorphic sarcoma
synovial sarcoma
neutrophil count
leiomyosarcoma
  • 0 views
  • 13 May, 2022
  • 1 location