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Found 40 clinical trials
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Avelumab in Combination With Gemcitabine in Advanced Leiomyosarcoma as a Second-line Treatment

A Phase 2 trial of avelumab plus gemcitabine in advanced leiomyosarcoma as a second line treatment

  • 0 views
  • 11 Feb, 2021
  • 7 locations
None
Pazopanib vs. Pazopanib Plus Gemcitabine

leiomyosarcomas or other metastatic uterine tumours.

  • 2 views
  • 28 Jan, 2021
  • 16 locations
None
Phase II Study of Regorafenib as Maintenance Therapy

Multicenter double-blind placebo-controlled randomized Phase II study comparing regorafenib to placebo, as maintenance therapy in metastatic soft-tissue non-adipocytic sarcomas experiencing stable disease or response after 6 cycles of doxorubicin-based chemotherapy as 1st line chemotherapy.

  • 2 views
  • 26 Jan, 2021
  • 29 locations
None
Safety Tolerability and Pharmacokinetics of an Anti-PD-1 Monoclonal Antibody in Subjects With Advanced Malignancies

The primary objective is to assess the safety and tolerability of Toripalimab in subjects with various advanced malignancies and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of Toripalimab, 2) evaluate antitumor activity of Toripalimab; 3) determine the immunogenicity of …

gastric cancer
monoclonal antibodies
systemic therapy
metastatic disease
measurable disease
  • 296 views
  • 03 May, 2021
  • 17 locations
None
Phase III Trial of Anlotinib Catequentinib in Advanced Alveolar Soft Part Sarcoma Leiomyosarcoma Synovial Sarcoma (APROMISS)

THIS STUDY IS CURRENTLY RECRUITING PATIENTS WITH ALVEOLAR SOFT PART SARCOMA ONLY AND IS NO LONGER RECRUITING PATIENTS WITH SYNOVIAL SARCOMA OR LEIOMYOSARCOMA.

synovial sarcoma
ejection fraction
renal function
systemic therapy
angiogenesis
  • 325 views
  • 01 Dec, 2021
  • 24 locations
None
Surgery With Our Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

(dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or

cancer chemotherapy
leiomyosarcoma
systemic therapy
measurable disease
ifosfamide
  • 0 views
  • 30 Jul, 2021
  • 23 locations
None
A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseases

The purpose of this study is to assess the efficacy and safety of tabelecleucel in participants with Epstein-Barr virus (EBV) associated diseases.

rituximab
cancer chemotherapy
systemic disease
bone marrow procedure
hypogammaglobulinemia
  • 0 views
  • 29 Nov, 2021
  • 30 locations
None
Metronomic Trabectedin Gemcitabine and Dacarbazine for Leiomyosarcoma

This is an open label phase 2 study using metronomic doses of trabectedin, gemcitabine and dacarbazine given intravenously.

dacarbazine
leiomyosarcoma
trabectedin
kidney function tests
platelet count
  • 0 views
  • 24 Sep, 2021
  • 1 location
None
CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma

The purpose of this study is to find out if giving a dose of heated chemotherapy in the abdomen immediately after surgery that is done to remove uterine leiomyosarcoma type of cancer will help

  • 0 views
  • 19 Feb, 2021
  • 1 location
None
A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

The purpose of this study is to find out whether combining the study drugs rucaparib and nivolumab may be an effective treatment for advanced and/or metastatic LMS, and whether the study treatment works as well as the standard chemotherapy for this type of cancer.

cancer chemotherapy
leiomyosarcoma
systemic therapy
measurable disease
immunomodulators
  • 0 views
  • 29 Sep, 2021
  • 7 locations