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Found 11 clinical trials
Early Left Atrial Septostomy Versus Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation

for hemodynamics. It can increase left ventricular end-diastolic pressure(LVEDP), followed by left ventricular dilatation, abnormal opening of aortic valve and jeopardizes of myocardial recovery

  • 30 Apr, 2021
  • 1 location
Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.

  • 10 Sep, 2021
  • 1 location
Mechanisms of Right Ventricular Adaptation in Patients With Heart Failure With Preserved Ejection Fraction

Biventricular PV-loop studies and advanced imaging to assess left-to-right ventricular interaction in HFpEF: In a group of 30 HFpEF patients with clinical indication for LH/RH catheter investigation, we will perform biventricular PV loop assessment in combination with extensive imaging (MRI, echo) for in-depth analysis of left-to-right ventricular interaction in the …

medical therapy
heart failure with preserved ejection fraction
ejection fraction
  • 25 Jan, 2021
  • 2 locations
ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions (NEPTUNE)

The NEPTUNE triple-blind, active-placebo, adaptive, pragmatic, randomized trial aims to evaluate the effectiveness of a new intra-venous hydration strategy guided by left ventricular end

  • 25 Mar, 2022
  • 1 location
DyeVert System and Contrast-induced Acute Kidney Injury (REMEDIALIV)

The aim of the REnal Insufficiency Following Contrast MEDIA Administration TriaL IV (REMEDIAL IV) is to test whether the use of the DyeVert system is effective in reducing CI-AKI rate in ACS patients undergoing urgent/immediate (within 2 hours) invasive diagnostic and/or interventional cardiovascular procedures. The DyeVert™ system (Osprey Medical Inc., …

medical therapy
myocardial infarction
acute coronary syndrome
  • 26 Mar, 2022
  • 1 location
Coronary Physiology Testing in Acute Coronary Syndromes (CoPhyTea)

This is an interventional, prospective, multicenter study (5 IRCCS hospitals belonging to the Italian Cardiology Network) in patients with STEMI treated with successful primary PCI to assess the ability of coronary physiology parameters measured soon after recanalization to predict myocardial tissue characterization assessed with cardiac magnetic resonance (CMR) within a …

heart failure
  • 18 Apr, 2022
  • 2 locations
Stratified Medicine of Eplerenone in Acute MI/Injury (StratMed-MINOCA)

Patients with heart attack or heart injury are tested (angiogram) for blockages in their arteries. Many patients develop heart problems caused by damage to small (microvascular) blood vessels. These issues are also relevant to patients with coronarvirus-19 disease (COVID-19). Eplerenone reduces blood vessel injury and is used to treat heart …

  • 18 May, 2022
  • 1 location
PITA-HF: Feasibility Safety and Tolerability

Heart failure affects over 25 million people worldwide and nearly 7 million adults in the United States alone. Nearly 25% of patients with heart failure have worsened disease burden from dyssynchronous ventricular contraction due to abnormal electrical impulse propagation. These patients may benefit from cardiac resynchronization therapy (CRT) where contraction …

cardiac resynchronization therapy
medical therapy
dilated cardiomyopathy
  • 20 Jun, 2021
  • 1 location
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy (SILICOFCM)

The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with hypertrophic cardiomyopathy (HCM). HCM is the most common genetic cardiovascular disease with a broad spectrum of disease severity. Angiotensin receptor …

hypertrophic obstructive cardiomyopathy
neprilysin inhibitor
  • 13 Feb, 2022
  • 2 locations
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms. (RIP-CI-AKI)

The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used. However, CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third most common cause of renal insufficiency, and its incidence varies from 2% to 50% …

  • 02 May, 2022