Found 24 clinical trials
Transcatheter Leak Closure With Detachable Coils Following Incomplete Left Atrial Appendage Closure Procedures
Although the clinical impact of left atrial appendage (LAA) leaks still requires confirmation, the open pouch with residual flow resulting from incomplete LAA closure may promote blood stagnation and thrombus formation, and increase the risk of thromboembolic events. The main purpose of this trial is to evaluate the safety and …
- 0 views
- 14 Apr, 2021
- 1 location
Evaluation od Safety and Performance of the Omega LAA (Left Atrial Appendage) Occluder and Omega Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk
The purpose of the study is to assess the safety and performance of the Omega LAA (Left Atrial Appendage) Occluder and Omega Delivery System in LAA (Left Atrial Appendage) closure for patients
- 0 views
- 08 Apr, 2021
- 1 location
Computational Simulation to Plan for Percutaneous Left Atrial Appendage Closure
To ensure a successful percutaneous left atrial appendage (LAA) closure, it is important to select the correct size of the closure device used for each patient. To define and measure the size of the LAA, 2D transesophageal echocardiography (TEE) has been typically used. An increasing number of hospitals recently switched …
- 0 views
- 24 Jan, 2021
- 10 locations
Left Atrial Appendage CLOSURE for the Prevention of Thromboembolisms in Patients Undergoing Aortic Bioprosthesis Surgery
The primary purpose of the LAA-CLOSURE trial is to assess the efficacy and safety of surgical closure of LAA in patients undergoing aortic valve replacement. This randomized, prospective, open-label international multicenter trial will enroll 1040 patients undergoing aortic valve replacement with CHA2DS2-VASC score 2 but without an indication for anticoagulation …
- 0 views
- 10 May, 2021
- 4 locations
Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy
The study goal is to determine the clinical benefit of percutaneous catheter-based left atrial appendage (LAA) closure in patients with non-valvular atrial fibrillation (NVAF) at high risk of stroke (CHA2DS2-VASc Score 2) as well as high risk of bleeding as compared to best medical care (including a [non-vitamin K] oral …
- 13 views
- 05 Aug, 2021
- 44 locations
Prevention of Stroke by Left Atrial Appendage Closure in Atrial Fibrillation Patients After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) in patients with non-valvular atrial fibrillation (NVAF) poses a particular dilemma for thromboprophylaxis. Left atrial appendage occlusion (LAAO) is a non-pharmacological approach to prevent cardiac embolism in NVAF. The risk-benefit ratio of LAAO in patients with NVAF after ICH is unknown. The aim of STROKECLOSE is to …
- 1 views
- 21 Jan, 2021
- 2 locations
CHAMPION-AF Clinical Trial
The primary objective of this study is to determine if left atrial appendage closure with the WATCHMAN FLX device is a reasonable alternative to non-vitamin K oral anticoagulants in patients
- 0 views
- 12 Sep, 2021
- 91 locations
Left Atrium Appendage Closure by Surgery-2
to support the efficacy and safety of this practice. We therefore conducted the Left Atrial Appendage Closure by Surgery (LAACS) study (2010-2016) were patients in whom the appendage was
- 0 views
- 30 Apr, 2021
- 6 locations
Optimal Antiplatelet Therapy Following Left Atrial Appendage Closure
SAFE-LAAC Trial has been designed to gather data on the most optimal strategy of antiplatelet therapy after transcatheter left atrial appendage occlusion with Amplatzer Amulet device
- 19 views
- 22 Jan, 2021
- 1 location
Evaluating the Safety and Effectiveness of the Laminar Left Atrial Appendage Closure System
The objective of this study is to demonstrate safety and effectiveness using a percutaneous Delivery System of the Laminar Left Atrial Appendage Closure System to treat patients with NVAF to
- 0 views
- 25 Mar, 2021
- 2 locations