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Found 15 clinical trials
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Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients

This phase II trial studies the effects of leflunomide in treating African-American and European-American patients with high-risk smoldering multiple myeloma. Leflunomide is used to decrease the

  • 0 views
  • 15 Oct, 2021
  • 3 locations
None
The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus in Treatment of BK Virus Infection in Kidney Transplantation Recipient

kidney transplant recipient. However, there are evidences from retrospective and prospective studies showed that leflunomide and mTOR inhibitor such as everolimus or sirolimus have positive outcomes in

  • 0 views
  • 11 May, 2021
  • 1 location
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Severe Psoriatic Arthritis - Early intervEntion to Control Disease: the SPEED Trial

SPEED is a three arm interventional trial nested within a cohort (Trials Within Cohorts or TWiCs design). This tests more aggressive early therapy in patients newly diagnosed with moderate to severe PsA. Arm 1 will receive standard step up therapy in the cohort and act as the control group. Arm …

sulfasalazine
arthritis
methotrexate
tumour necrosis
tumor necrosis factor
  • 2 views
  • 05 May, 2021
  • 1 location
None
Molecular Effects of Apremilast in the Synovium of Psoriatic Arthritis Patients

This study assess the genomics profiles in synovial biopsies obtained prior to, and 24 weeks after an immunomodulator agent (Apremilast) in patients with active psoriatic arthritis who are naive to treatment with a conventional synthetic DMARDs (such as methotrexate).

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
Immune Response to SARS-CoV-2/COVID-19 Vaccination in Sarcoidosis

People with sarcoidosis, particularly those with significant lung and/or cardiac involvement, who become infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) are likely at increased risk of complications or death from COVID-19. While SARS-CoV-2 vaccines are highly efficacious in preventing COVID-19 in the general population, whether vaccination provides similar protection in …

Accepts healthy volunteers
  • 0 views
  • 08 Dec, 2021
  • 1 location