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Found 15 clinical trials
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired health-related quality of life. As a chronic disease, rheumatoid Chronic arthritis needs long-term treatment. At the same time, RA can cause skin, eye, …

synovitis
tofacitinib
stiffness
DMARD
antirheumatics
  • 8 views
  • 22 Jun, 2021
  • 1 location
Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + Sulfasalazine + Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate or Leflunomide (BIO3)

), methotrexate or leflunomide+salazopyrine+hydroxychloroquine could be an alternative option to targeted therapies, all the more as they have a more favorable safety profile and a much lower cost. Uncertainty

sulfasalazine
cyclic citrullinated peptide antibody
etanercept
tumor necrosis factor
tocilizumab
  • 0 views
  • 24 Jul, 2022
  • 1 location
Treatment With Leflunomide in Patients With Polymyalgia Rheumatica (PMRLEFRCT)

corticosteroid-sparing agent. Studies on tumor necrosis factor (TNF) blockers yielded negative results. The effectiveness of leflunomide has only been convincingly demonstrated in case series. The high

increasing awareness
prednisolone
leflunomide 20 mg
glucocorticoids
polymyalgia
  • 233 views
  • 09 Feb, 2022
  • 2 locations
Leflunomide in Previously Treated Metastatic Triple Negative Cancers

study is to determine the safety, tolerability and maximum tolerated dose of leflunomide in women with previously treated TNBC. The primary objective of the phase 2 part of this study is to determine

breast cancer
stage iv breast cancer
triple negative breast cancer
cancer
progesterone receptor
  • 10 views
  • 16 Jun, 2022
  • 3 locations
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

usually needed for prolonged periods, and cause a large number of additional problems in transplant patients. Leflunomide is a drug which has been used for several years in diseases like rheumatoid

  • 0 views
  • 28 Jun, 2021
  • 1 location
Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

This phase I trial studies the side effects of leflunomide in treating patients with steroid dependent chronic graft versus host disease (cGVHD). cGVHD is a common complication of bone marrow

neutrophil count
cell transplantation
platelet transfusions
sirolimus
cytopenia
  • 0 views
  • 11 Sep, 2021
  • 1 location
Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

This phase II trial studies how well leflunomide, pomalidomide, and dexamethasone work for the treatment of multiple myeloma that has come back (relapsed) or does not respond to treatment

refractory multiple myeloma
immunoglobulin
cancer
electrophoresis
platelet count
  • 0 views
  • 25 Mar, 2022
  • 1 location
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy

This phase I/II trial investigates the best dose and side effects of leflunomide and how well it works in treating patients with COVID-19 and a past or present cancer. Leflunomide has been used

cancer
  • 2 views
  • 26 May, 2022
  • 1 location
Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis

This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is

cyclophosphamide
azathioprine
leflunomide
rituximab
  • 0 views
  • 06 Dec, 2021
  • 4 locations
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients

This phase II trial studies the effects of leflunomide in treating African-American and European-American patients with high-risk smoldering multiple myeloma. Leflunomide is used to decrease the

  • 0 views
  • 01 May, 2022
  • 1 location