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Found 15 clinical trials
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Leflunomide Associated With Topical Corticosteroids for Bullous Pemphigoid

immunosuppressive drugs have suggested by uncontrolled study. In this way, leflunomide could be an alternative therapy, and to reduce relapse and/or resistance risks. This study could prove the

  • 1 views
  • 07 Nov, 2020
  • 1 location
None
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired health-related quality of life. As a chronic disease, rheumatoid Chronic arthritis needs long-term treatment. At the same time, RA can cause skin, eye, …

antirheumatics
DMARD
stiffness
synovitis
tofacitinib
  • 0 views
  • 22 Jun, 2021
  • 1 location
None
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

usually needed for prolonged periods, and cause a large number of additional problems in transplant patients. Leflunomide is a drug which has been used for several years in diseases like rheumatoid

  • 0 views
  • 28 Jun, 2021
  • 1 location
None
Leflunomide in Previously Treated Metastatic Triple Negative Cancers

study is to determine the safety, tolerability and maximum tolerated dose of leflunomide in women with previously treated TNBC. The primary objective of the phase 2 part of this study is to determine

breast cancer
stage iv breast cancer
estrogen
cancer
triple negative breast cancer
  • 10 views
  • 23 Jan, 2021
  • 1 location
None
Treatment With Leflunomide in Patients With Polymyalgia Rheumatica

corticosteroid-sparing agent. Studies on tumor necrosis factor (TNF) blockers yielded negative results. The effectiveness of leflunomide has only been convincingly demonstrated in case series. The high

corticosteroids
glucocorticoids
leflunomide 20 mg
arthritis
polymyalgia
  • 93 views
  • 22 Jan, 2021
  • 2 locations
None
Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

This phase I trial studies the side effects of leflunomide in treating patients with steroid dependent chronic graft versus host disease (cGVHD). cGVHD is a common complication of bone marrow

sirolimus
bone marrow transplant
neutrophil count
prednisone
platelet transfusions
  • 0 views
  • 11 Sep, 2021
  • 1 location
None
Leflunomide for the Treatment of Relapsed or Refractory CD30+ Lymphoproliferative Disorders

This trial studies how well leflunomide works for the treatment of patients with CD30+ lymphoproliferative disorders that have come back (relapsed) or do not respond to treatment (refractory

  • 0 views
  • 21 Aug, 2021
  • 1 location
None
Leflunomide Plus Low Dose Corticosteroid in Immunoglobulin A (IgA) Nephropathy With Renal Insufficiency

immunosuppressive therapy is still controversial, especially to those progressive IgA nephropathy with eGFR<50ml/min. Leflunomide is widely used in the treatment of rheumatic diseases, such as rheumatoid

chronic kidney disease
glomerulonephritis
renal failure
glucocorticoids
immunoglobulins
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Leflunomide Pomalidomide and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

This phase II trial studies how well leflunomide, pomalidomide, and dexamethasone work for the treatment of multiple myeloma that has come back (relapsed) or does not respond to treatment

serum protein
chemotherapy drugs
colony stimulating factor
g-csf
measurable disease
  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy

This phase I/II trial investigates the best dose and side effects of leflunomide and how well it works in treating patients with COVID-19 and a past or present cancer. Leflunomide has been used

  • 0 views
  • 14 May, 2021
  • 1 location