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Found 14 clinical trials
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired health-related quality of life. As a chronic disease, rheumatoid Chronic arthritis needs long-term treatment. At the same time, RA can cause skin, eye, …

DMARD
synovitis
tofacitinib
antirheumatics
stiffness
  • 8 views
  • 22 Jun, 2021
  • 1 location
Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + Sulfasalazine + Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate or Leflunomide (BIO3)

), methotrexate or leflunomide+salazopyrine+hydroxychloroquine could be an alternative option to targeted therapies, all the more as they have a more favorable safety profile and a much lower cost. Uncertainty

tumor necrosis factor
DMARD
hydroxychloroquine
abatacept
adalimumab
  • 0 views
  • 04 Oct, 2022
  • 1 location
Leflunomide in Previously Treated Metastatic Triple Negative Cancers

study is to determine the safety, tolerability and maximum tolerated dose of leflunomide in women with previously treated TNBC. The primary objective of the phase 2 part of this study is to determine

cancer
metastasis
breast cancer
estrogen
triple negative breast cancer
  • 10 views
  • 16 Jun, 2022
  • 3 locations
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

usually needed for prolonged periods, and cause a large number of additional problems in transplant patients. Leflunomide is a drug which has been used for several years in diseases like rheumatoid

  • 0 views
  • 28 Jun, 2021
  • 1 location
Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

This phase II trial studies how well leflunomide, pomalidomide, and dexamethasone work for the treatment of multiple myeloma that has come back (relapsed) or does not respond to treatment

colony stimulating factor
dexamethasone
immunoglobulin
cancer
gilbert's syndrome
  • 0 views
  • 25 Mar, 2022
  • 1 location
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy

This phase I/II trial investigates the best dose and side effects of leflunomide and how well it works in treating patients with COVID-19 and a past or present cancer. Leflunomide has been used

cancer
  • 2 views
  • 26 May, 2022
  • 1 location
Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis

This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is

azathioprine
leflunomide
cyclophosphamide
rituximab
  • 0 views
  • 06 Dec, 2021
  • 4 locations
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients

This phase II trial studies the effects of leflunomide in treating African-American and European-American patients with high-risk smoldering multiple myeloma. Leflunomide is used to decrease the

  • 0 views
  • 01 May, 2022
  • 1 location
A Safety and Feasibility Trial of Leflunomide in Patients With Steroid Dependent Chronic Graft-Versus-Host Disease

This phase I trial studies the side effects of leflunomide in treating patients with steroid dependent chronic graft versus host disease (cGVHD). cGVHD is a common complication of bone marrow

leflunomide
corticosteroids
sirolimus
platelet transfusions
cell transplantation
  • 0 views
  • 18 Oct, 2022
  • 1 location
Takayasu Arteritis Clinical Trial in China (TACTIC)

The purpose of this study is to investigate the efficacy and Safety of Leflunomide in Patients With Active Phase of Takayasu's Arteritis

methotrexate
erythrocyte sedimentation
claudication
ischemia
cholestyramine
  • 0 views
  • 09 Jul, 2022
  • 7 locations