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Found 14 clinical trials
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired health-related quality of life. As a chronic disease, rheumatoid Chronic arthritis needs long-term treatment. At the same time, RA can cause skin, eye, …

antirheumatics
stiffness
DMARD
synovitis
tofacitinib
  • 8 views
  • 22 Jun, 2021
  • 1 location
Leflunomide in Previously Treated Metastatic Triple Negative Cancers

study is to determine the safety, tolerability and maximum tolerated dose of leflunomide in women with previously treated TNBC. The primary objective of the phase 2 part of this study is to determine

stage iv breast cancer
metastasis
triple negative breast cancer
estrogen
erbb2
  • 10 views
  • 02 Feb, 2022
  • 3 locations
Treatment With Leflunomide in Patients With Polymyalgia Rheumatica (PMRLEFRCT)

corticosteroid-sparing agent. Studies on tumor necrosis factor (TNF) blockers yielded negative results. The effectiveness of leflunomide has only been convincingly demonstrated in case series. The high

rheumatoid arthritis
methotrexate
leflunomide 20 mg
tumor necrosis factor
tumor necrosis factor alpha
  • 228 views
  • 09 Feb, 2022
  • 2 locations
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

usually needed for prolonged periods, and cause a large number of additional problems in transplant patients. Leflunomide is a drug which has been used for several years in diseases like rheumatoid

  • 0 views
  • 28 Jun, 2021
  • 1 location
Leflunomide Plus Low Dose Corticosteroid in Immunoglobulin A (IgA) Nephropathy With Renal Insufficiency

immunosuppressive therapy is still controversial, especially to those progressive IgA nephropathy with eGFR<50ml/min. Leflunomide is widely used in the treatment of rheumatic diseases, such as rheumatoid

rheumatoid arthritis
corticosteroids
glomerulonephritis
glomerular filtration rate
renal failure
  • 0 views
  • 27 Feb, 2022
  • 1 location
Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

This phase I trial studies the side effects of leflunomide in treating patients with steroid dependent chronic graft versus host disease (cGVHD). cGVHD is a common complication of bone marrow

serum pregnancy test
cytopenia
bone marrow transplant
urine test
platelet transfusions
  • 0 views
  • 11 Sep, 2021
  • 1 location
Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

This phase II trial studies how well leflunomide, pomalidomide, and dexamethasone work for the treatment of multiple myeloma that has come back (relapsed) or does not respond to treatment

neutrophil count
immunoglobulin
pomalidomide
line of therapy
gilbert's syndrome
  • 0 views
  • 25 Mar, 2022
  • 1 location
Leflunomide for the Treatment of Relapsed or Refractory CD30+ Lymphoproliferative Disorders

This trial studies how well leflunomide works for the treatment of patients with CD30+ lymphoproliferative disorders that have come back (relapsed) or do not respond to treatment (refractory

  • 0 views
  • 21 Aug, 2021
  • 1 location
Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis

This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is

azathioprine
leflunomide
rituximab
cyclophosphamide
  • 0 views
  • 06 Dec, 2021
  • 4 locations
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy

This phase I/II trial investigates the best dose and side effects of leflunomide and how well it works in treating patients with COVID-19 and a past or present cancer. Leflunomide has been used

  • 2 views
  • 14 May, 2021
  • 1 location