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Found 8 clinical trials
A Pilot Study of Larotectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

(Larotrectinib) have been given. The study will also evaluate the safety of larotrectinib when given with chemotherapy in your children; as well as the safety larotrectinib when given post-focal radiation

  • 0 views
  • 02 May, 2021
  • 17 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3

tyrosine
measurable disease
lung cancer
breast cancer
NTRK
  • 0 views
  • 03 Jun, 2021
  • 195 locations
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children

The study is being done to test the safety of a cancer drug called larotrectinib in children. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib blocks the

primary cancer
metastatic solid tumor
solid tumor
breast cancer
metastasis
  • 0 views
  • 20 Jun, 2021
  • 72 locations
Larotrectinib for the Treatment of NTRK Amplification Positive Locally Advanced or Metastatic Solid Tumors

This phase II trial studies the effect of larotrectinib in treating patients with NTRK gene amplification positive solid tumors that have spread to nearby tissues or lymph nodes (locally

  • 0 views
  • 16 May, 2021
  • 1 location
Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia

This phase II trial studies the side effects and how well larotrectinib works in treating patients with previously untreated TRK fusion solid tumors and TRK fusion acute leukemia that has come

vincristine
cancer treatment
glomerular filtration rate
platelet count
cancer
  • 3 views
  • 31 May, 2021
  • 35 locations
Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well larotrectinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that have spread

cns tumors
radiopharmaceutical therapy
glomerular filtration rate
platelet count
stem cell transplantation
  • 351 views
  • 23 Jun, 2021
  • 83 locations
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body

In this observational study researcher want to learn more about the effectiveness of drug VITRAKVI (generic name: larotrectinib) and how well the drug is tolerated during routine use in patients

  • 2 views
  • 20 Jun, 2021
  • 50 locations
A Retro-/Prospective Non-interventional Cohort Study in Adult Patients With Locally Advanced or Metastatic Tumors With a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion Treated With Larotrectinib

Larotrectinib, a selective TRK inhibitor has showed marked and durable antitumor activity in patients with NTRK gene-fusion-positive tumors regardless of the tumor type, gene partner and

  • 0 views
  • 02 Apr, 2021
  • 4 locations