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Found 13 clinical trials
A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

The main objective of this trail is to investigate if and to what extent BI 409306, BI 425809 and lamotrigine attenuate ketamine induced cognitive deficits.

Accepts healthy volunteers
  • 49 views
  • 10 May, 2022
  • 2 locations
MExiletine Versus Lamotrigine in Non-Dystrophic Myotonias

This is a clinical trial to determine if Lamotrigine is non-inferior to Mexiletine for the treatment of myotonia in patients with Non-Dystrophic Myotonia. Non-dystrophic Myotonia is a

  • 0 views
  • 03 Sep, 2021
  • 1 location
Enhancing the Effects of Alcohol Treatment With Lamotrigine

This study will help determine the tolerability and efficacy of the mood-stabilizing anticonvulsant lamotrigine in youth with alcohol use disorder. It will also help establish whether and how

  • 0 views
  • 11 May, 2022
  • 1 location
Synaptic Plasticity and Cognitive Function in RASopathies (SynCoRAS)

. This has been done by the applicants successfully for Lovastatin in Nf1. This result will be transferred to patients with Noonan Syndrome. lamotrigine is most likely a more effective and promising

  • 17 views
  • 24 May, 2022
  • 1 location
Generating Evidence on NonEpileptic Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas

depression rather than epileptic discharges. After an intensive literature review, the investigators found out that some antiepileptic dugs (Lamotrigine, Topiramate) were found to be efficient to treat

  • 0 views
  • 07 May, 2021
  • 1 location
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual …

depressive symptoms
depressed mood
depressive disorder
bipolar disorder
major depressive disorder
  • 58 views
  • 12 Mar, 2022
Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression

The overall objective of the investigators is to assess the therapeutic efficacy and tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant bipolar depression patient (TRBD).

  • 0 views
  • 27 May, 2022
  • 1 location
Ketogenic Diet for New-Onset Absence Epilepsy

The ketogenic diet is a medical therapy for epilepsy that is used nearly predominantly for refractory epilepsy (after 2-3 drugs have been tried and failed). However, there is both published evidence for first-line use (infantile spasms, Glut1 deficiency syndrome) and also anecdotal experience (families choosing to change the child's (or …

  • 0 views
  • 15 Aug, 2021
  • 1 location
Saxenda® in Obese or Overweight Patients With Stable Bipolar Disorder (Investigator Initiated)

Taken together these data support the hypothesis that liraglutide 3.0 mg sc injection will reduce body weight and improve metabolic variables in obese or overweight patients with BP without worsening psychiatric symptoms. The investigators predict that liraglutide 3.0 mg sc injection will display greater efficacy as compared to placebo in …

antipsychotics
type 2 diabetes mellitus
liraglutide
schizoaffective disorder
benzodiazepines
  • 620 views
  • 24 Feb, 2022
  • 1 location
Population Pharmacokinetics of Antiepileptic in Pediatrics

The purpose of this study is to develop population pharmacokinetic models for antiepileptic drugs in a pediatric population. The interest of these models is multiple: describe the pharmacokinetics of these molecules in children and explain the inter-individual variability of concentrations through covariates such as weight, age, co-treatments, genetic polymorphisms and …

lamotrigine
perampanel
phenytoin
clobazam
levetiracetam
  • 21 views
  • 25 Jan, 2021
  • 1 location