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Found 13 clinical trials
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Influence of Dexmedetomidine or Propofol on ICU Delirium

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am after diagnosis of hyperactive or mixed delirium, decreases the duration of delirium. The infusions might have to be repeated …

dexmedetomidine
propofol
  • 0 views
  • 09 May, 2021
  • 1 location
None
The KHENEREXT Study

This is an open-label, multi-centre study in subjects with a genetically confirmed mitochondrial deoxyribonucleic acid (DNA) transfer ribonucleic acid (tRNA)Leu(UUR) m.3243A>G mutation who completed study KH176-202. In the KH176-203 study subjects will be receiving KH176 100 mg BID or KH176 50 mg bid in die (BID) (as determined by the …

  • 0 views
  • 03 Nov, 2021
  • 4 locations
None
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:

dehydrogenase complex (PDC). PDC deficiency (PDCD) is the most common cause of congenital lactic acidosis and is a frequently fatal metabolic disease of childhood for which no proven treatment exists. The

  • 2 views
  • 08 Sep, 2021
  • 9 locations
None
L-Citrulline Dose Finding Safety Study in MELAS

metabolism called Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS). Once established, this dose will be used in a future clinical trial.

  • 0 views
  • 08 Sep, 2021
  • 1 location
None
Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients

related to the safety of metformin in such diabetic patients due to the risk of lactic acidosis. However, recent studies showed that metformin was safe or even beneficial in HF patients. We hypothesized

angiotensin ii receptor antagonists
heart failure
beta blockers
ejection fraction
metformin
  • 0 views
  • 16 Jan, 2022
  • 1 location
None
Oral Anti Diabetic Agents in the Hospital

This randomized controlled clinical trial will assess whether continuation of home oral antidiabetic agents during hospitalization can be used as a safe and effective alternative to insulin therapy in the management of diabetes in the hospital. The primary outcome of the study is to determine differences in glycemic control as …

insulin
diabetic ketoacidosis
flash
antidiabetic agents
continuous glucose monitoring
  • 10 views
  • 04 Jul, 2021
  • 3 locations
None
Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Monotherapy With Tenofovir in ACLF-HBV

A randomized controlled trial to study the efficacy of addition of FMT & plasma exchange to tenofovir compared to monotherapy with tenofovir in patients with HBV reactivation who develops Acute on chronic liver failure. In this study the patients who meet the inclusion criteria will be randomized to either receive …

acute on chronic liver failure
plasma exchange
hepatic failure
tenofovir
  • 19 views
  • 25 Jan, 2021
  • 1 location
None
Comparison of Bolus Versus Continuous Infusion of Terlipressin Cirrhotic Patients With Septic Shock.

Septic shock is a major life-threatening vasodilatory shock. Vasopressor form a crucial pharmacotherapeutic option and have long been used as the first and foremost recommended therapy.(1) However, some patients may remain refractory to catecholamine, which is also known as catecholamine-resistant septic shock.(2, 3) High-dose catecholamine therapy may lead to potential …

vasopressin
norepinephrine
shock
terlipressin
  • 0 views
  • 20 Nov, 2021
  • 1 location
None
Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection

To address Aim 1, the investigators will conduct an open-label healthy volunteer study. The study team will recruit 48 healthy adult subjects aged 21-40 years, with a Body Mass Index of 20-25 kg/m2, have no known drug allergies and are not currently receiving regular immune-modulating therapy such as metformin, NSAIDs, …

  • 0 views
  • 26 Mar, 2021
  • 1 location
None
Intravenous Fluids in Adults With Diabetic Ketoacidosis in the Emergency Department

Diabetes mellitus is a common chronic disease. It is estimated that up to 40% of adults may develop diabetes in their lifetime. Patients with poorly controlled blood sugars often visit the emergency department for treatment of potentially dangerous and life-threatening complications of diabetes, including "diabetic ketoacidosis" (DKA), a condition where …

insulin
diabetic ketoacidosis
sugars
plasma glucose
chronic disease
  • 0 views
  • 19 Nov, 2021
  • 1 location