Found 33 clinical trials
Pharmacokinetic Study of Vancomycin, Clindamycin and/or Gentamicin Administration During Surgery Using a Microdialysis Procedure
infections. The beta-lactam are the most frequent antibiotics recommended for surgical prophylaxis and patients known to be allergic to beta-lactam are more likely to presented surgical site infection
- 0 views
- 09 Feb, 2022
- 1 location
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia (ACCESS)
prove that addition of oral clarithromycin to a β-lactam rapidly attenuates the high inflammatory burden of the host in CAP.
- 0 views
- 19 Apr, 2022
- 7 locations
Addition of Probenecid to Penicillin-V Therapy (ADDPROPEN)
a larger number of beta-lactam antibiotics. Hypothesis: Addition of probenecid to oral phenoxymethylpenicillin (penicillin-V) has a clinically relevant effect on pharmacokinetic
- 0 views
- 03 May, 2022
- 1 location
SYN-004 Safety and Tolerability in Allo-HCT Subjects
with IV β-lactam antibiotics meropenem (MER), piperacillin tazobactam (PIP/TAZO), or cefepime (FEP). To evaluate potential absorption of oral SYN-004 into the systemic
- 0 views
- 30 Apr, 2022
- 1 location
Temocillin Pharmacokinetics in Paediatrics (TEMOPEDI)
Temocillin (6-methoxy-ticarcillin) is a beta-lactam antibiotic with exceptional resistance to most beta-lactamases. In this context, it is now increasingly used as carbapenem-sparing antibiotic
- 7 views
- 15 Jun, 2022
- 1 location
Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)
to examine the effects of two commonly used antibiotics (the beta-lactam, amoxicillin and the macrolide azithromycin) on human microbial populations and on metabolic and immune physiology, studying
- 0 views
- 13 Jun, 2022
- 1 location
Phase 1 Oral QPX7831 SAD and MAD in Healthy Adults
This Phase 1 study will assess the safety, tolerability, and pharmacokinetics (PK) of QPX7831, a beta-lactamase inhibitor, when administered orally in single ascending doses and in multiple ascending doses to heathy adult subjects.
- 0 views
- 05 May, 2022
- 1 location
Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections (TANGOKIDS)
A single dose infusion of Vabomere (meropenem-vaborbactam) is being tested for dose-finding, pharmacokinetics, safety, and tolerability in pediatric subjects from birth to less than 18 years of age with serious bacterial infections
- 5 views
- 26 Jan, 2022
- 5 locations
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay. The appropriate and timely use of prophylactic antibiotics is found to reduce the prevalence of SSIs. At present, several regimen of …
- 0 views
- 15 Jun, 2022
- 1 location
ZAVI APD ELF Protocol v2.2
CAZ/AVI is a new antibiotic drug that is meant to be used for various indications including cIAI and nosocomial pneumonia. To date, limited data exists on PK of CAZ/AVI in patients undergoing peritoneal dialysis as well as on penetration of CAZ/AVI in ELF of critically ill patients. The present study …
- 48 views
- 28 Feb, 2022
- 1 location