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Found 20 clinical trials
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men (RHYTHM)

Objectives The overall clinical question is whether LH supplementation to men in indication for FSH according to the AIFA note 74, or with HH, will improve spermatogenesis and pregnancy rate (spontaneous or after ART) over FSH alone or FSH+hCG. However, since LH has never been used in men so far, …

  • 0 views
  • 05 Mar, 2022
Very Large Sizes in Adolescents : Tibial and Femoral EPIphysiodesis (GREPI)

The very large sizes can be very disabling and at the origin of a difficult psychological experience. Some families are in demand for a growth-curbing treatment. Currently, only hormonal treatments are offered in France but they are at the origin of many side effects. Northern European countries applied a surgical …

  • 0 views
  • 20 Jul, 2022
  • 4 locations
A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism

Testosterone is the principal androgen produced by the male testes. Hypogonadism is the result of inadequate production of testosterone by the Leydig cells of the testes and is reflected by total serum concentrations of testosterone of < 300 nanograms (ng)/deciliters (dL), with discernible diurnal pattern. The etiology of hypogonadism may …

replacement therapy
hypogonadism
androgens
serum testosterone
testosterone
  • 140 views
  • 28 May, 2022
  • 24 locations
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism

The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.

kisspeptin
secondary hypogonadism
klinefelter syndrome
  • 0 views
  • 08 Jul, 2022
  • 1 location
Opioid Antagonism in Hypogonadotropic Hypogonadism

The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).

kisspeptin
secondary hypogonadism
pituitary
idiopathic hypogonadotropic hypogonadism
klinefelter syndrome
  • 0 views
  • 07 Jul, 2022
  • 1 location
Neuropeptides in Human Reproduction

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of GnRH and kisspeptin, 2 …

gonadotropin
hypogonadism
prolactin
Accepts healthy volunteers
screening procedure
  • 98 views
  • 07 Jul, 2022
  • 1 location
Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH

The Hypogonadotropic Hypogonadism(HH) could be caused by sellar lesions, sellar surgery or sellar radiotherapy. The incidence of HH after sellar surgery was higher in men than in women, and the

secondary hypogonadism
pituitary
gonadotropin
luteinizing hormone
klinefelter syndrome
  • 0 views
  • 25 Mar, 2022
  • 1 location
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial

The overall objective of this randomized trial is to investigate the effects of treatment of AAS- induced male hypogonadism with combined therapy of letrozole and hCG compared with placebo on reproductive hormone levels, adherence to cessation of AAS use, fertility, cardiac function and quality of life.

testosterone
male hypogonadism
testosterone level
hormone levels
screening procedure
  • 0 views
  • 23 Mar, 2022
  • 1 location
Kisspeptin in the Evaluation of Delayed Puberty

Some children with delayed puberty will eventually enter puberty on their own. However, some children with delayed puberty have a permanent condition and require medical treatment to undergo puberty. Right now, there is no reliable diagnostic tool to tell whether a child's delayed puberty will be self-resolving or permanent. The …

prolactin
testosterone
insulin
testicular
insulin-like growth factor
  • 23 views
  • 24 Jul, 2022
  • 1 location
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism

The investigators have preliminary data suggesting that obese patients with hypogonadotropic hypogonadism (HHG) have minimal benefit from testosterone therapy likely because of its conversion to

pituitary
gonadotropin
androgens
testosterone
behavior modification
  • 1129 views
  • 24 Mar, 2022
  • 1 location