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Found 323 clinical trials
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

brain metastases
immunodeficiency
fgfr inhibitor azd4547
dabrafenib
screening method
  • 6595 views
  • 20 Oct, 2022
  • 906 locations
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.

  • 0 views
  • 04 Oct, 2022
  • 23 locations
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.

  • 1 views
  • 04 Oct, 2022
  • 23 locations
A Phase 2 Basket Study of the Oral TRK Inhibitor Larotrectinib in Subjects With NTRK Fusion-positive Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

lung carcinoma
NTRK
lung cancer
tyrosine
cancer
  • 163 views
  • 21 Oct, 2022
  • 125 locations
A Phase I First-in-Human Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD8701 Administered Intravenously as Monotherapy and in Combination With Durvaluamb (MEDI4736) in Participants With Advanced Solid Tumours.

The purpose of this study is to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of AZD8701 Alone and in Combination with Durvalumab (MEDI4736) in Adult Subjects with Select Advanced Solid Tumors

lung carcinoma
durvalumab
ct scan
progressive disease
triple negative breast cancer
  • 52 views
  • 28 Oct, 2022
  • 13 locations
Evaluation of the Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

Background People with von Hippel-Lindau (VHL) can have problems with a variety of organs, such as the pancreas. The disease can cause tumors of the pancreas. This can result in life-threatening complications. Researchers want to learn more about these pancreatic tumors and how to better detect them. This may help …

dotatate
genetic testing
ct scan
cyst
pet/ct scan
  • 0 views
  • 28 Oct, 2022
  • 1 location
Pencil Beam Scanning in Patients With Renal Tumors

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

beam radiation
anaplasia
nephroblastoma
sarcoma
renal neoplasm
  • 15 views
  • 04 Oct, 2022
  • 1 location
Percutaneous Cryoablation Versus Partial Nephrectomy for T1b Renal Tumor

The aim of our study is to assess the long-term oncological and functional outcomes of cryoablation for T1b renal tumors, as well as such important parameters as the patient's quality of life

nephrectomy
renal neoplasm
  • 0 views
  • 06 Aug, 2021
  • 1 location
SBRT With Combination Ipilimumab/Nivolumab for Metastatic Kidney Cancer (CYTOSHRINK)

treatment of metastatic kidney cancer.

metastasis
ipilimumab
kidney cancer
nivolumab
cancer
  • 1 views
  • 23 Apr, 2022
  • 6 locations
Phase II Study: Stereotactic Ablative Radiotherapy for Renal Tumors

Renal Cell Carcinoma (RCC) is the most common type of kidney cancer. The usual treatment for this type of cancer is surgery. Considering the most common patients are an average age of 65 and

metastasis
carcinoma
kidney cancer
cancer
renal neoplasm
  • 13 views
  • 21 Oct, 2022
  • 1 location